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Thomas Wienker

Explore the profile of Thomas Wienker including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 21
Citations 686
Followers 0
Related Specialties
Psychiatry
Genetics
General Medicine
Top 10 Co-Authors
Amalia Diaz-Lacava
Falk Kiefer
Norbert Dahmen
Jurgen Gallinat
Arian Mobascher
Michael Wagner
Georg Winterer
Christoph von der Goltz
Norbert Thuerauf
Gerhard Grunder
Published In
Addict Biol
PLoS One
Hum Mol Genet
J Am Soc Nephrol
Otol Neurotol
Affiliations
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Recent Articles
1.
Creation of a structured molecular genomics report for Germany as a local adaption of HL7's Genomic Reporting Implementation Guide
Stellmach C, Sass J, Auber B, Boeker M, Wienker T, Heidel A, et al.
J Am Med Inform Assoc . 2023 Apr; 30(6):1179-1189. PMID: 37080557
Objective: The objective was to develop a dataset definition, information model, and FHIR® specification for key data elements contained in a German molecular genomics (MolGen) report to facilitate genomic and...
2.
Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability
Musante L, Puttmann L, Kahrizi K, Garshasbi M, Hu H, Stehr H, et al.
Hum Mutat . 2017 Feb; 38(6):621-636. PMID: 28236339
Intellectual disability (ID) is the hallmark of an extremely heterogeneous group of disorders that comprises a wide variety of syndromic and non-syndromic phenotypes. Here, we report on mutations in two...
3.
Penetrance of pathogenic mutations in haploinsufficient genes for intellectual disability and related disorders
Ropers H, Wienker T
Eur J Med Genet . 2015 Oct; 58(12):715-8. PMID: 26506440
De novo loss of function (LOF) mutations in the ASXL3 gene cause Bainbridge-Ropers syndrome, a severe form of intellectual disability (ID) and developmental delay, but there is evidence that they...
4.
New evidence for the role of calpain 10 in autosomal recessive intellectual disability: identification of two novel nonsense variants by exome sequencing in Iranian families
Oladnabi M, Musante L, Larti F, Hu H, Abedini S, Wienker T, et al.
Arch Iran Med . 2015 Mar; 18(3):179-84. PMID: 25773692
Background: Knowledge of the genes responsible for intellectual disability, particularly autosomal recessive forms, is rapidly expanding. Increasing numbers of the gene show great heterogeneity and supports the hypothesis that human...
5.
Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women
Mutschler J, Abbruzzese E, Wiedemann K, von der Goltz C, Dinter C, Mobascher A, et al.
Ann Nutr Metab . 2013 May; 62(4):271-6. PMID: 23652383
Objective: The neuropeptide-Y (NP-Y) gene is a strong candidate gene in the pathophysiology of obesity-linked behavior, and several single-nucleotide polymorphisms of NP-Y have already been linked to body weight and...
6.
Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study
Mutschler J, Abbruzzese E, von der Goltz C, Dinter C, Mobascher A, Thiele H, et al.
Nicotine Tob Res . 2013 Jan; 15(7):1322-7. PMID: 23288874
Background: The catechol-O-methyltransferase (COMT) modulates dopaminergic neurotransmission in the prefrontal cortex as well as in the mesolimbic reward system. Since the reward system mediates addictive behavior, the COMT gene is...
7.
Impaired sleep quality and sleep duration in smokers-results from the German Multicenter Study on Nicotine Dependence
Cohrs S, Rodenbeck A, Riemann D, Szagun B, Jaehne A, Brinkmeyer J, et al.
Addict Biol . 2012 Aug; 19(3):486-96. PMID: 22913370
Cigarette smoking is a severe health burden being related to a number of chronic diseases. Frequently, smokers report about sleep problems. Sleep disturbance, in turn, has been demonstrated to be...
8.
Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking
Mutschler J, Abbruzzese E, von der Goltz C, Dinter C, Mobascher A, Thiele H, et al.
Eur Addict Res . 2012 May; 18(5):246-52. PMID: 22584873
Background: Neuropeptide Y (NPY) is a strong candidate gene regarding the pathophysiology of tobacco dependence. It has been associated with various addictive and psychiatric disorders, and closely interacts with the...
9.
Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior
Wagner M, Schulze-Rauschenbach S, Petrovsky N, Brinkmeyer J, von der Goltz C, Grunder G, et al.
Addict Biol . 2012 Feb; 18(4):752-61. PMID: 22339903
The aim of the present study was to examine neurocognitive function associated with chronic nicotine use. A total of 2163 healthy participants (1002 smokers, 1161 never-smoking controls) participated in a...
10.
Methylation of L1Hs promoters is lower on the inactive X, has a tendency of being higher on autosomes in smaller genomes and shows inter-individual variability at some loci
Singer H, Walier M, Nusgen N, Meesters C, Schreiner F, Woelfle J, et al.
Hum Mol Genet . 2011 Oct; 21(1):219-35. PMID: 21972244
LINE-1 repeats account for ~17% of the human genome. Little is known about their individual methylation patterns, because their repetitive, almost identical sequences make them difficult to be individually targeted....