Thomas W Thorpe
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Explore the profile of Thomas W Thorpe including associated specialties, affiliations and a list of published articles.
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11
Citations
155
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Recent Articles
1.
Thorpe T, Marshall J, Turner N
J Am Chem Soc
. 2024 Mar;
146(12):7876-7884.
PMID: 38489244
Biocatalysis is becoming an indispensable tool in organic synthesis due to high enzymatic catalytic efficiency as well as exquisite chemo- and stereoselectivity. Some biocatalysts display great promiscuity including a broad...
2.
Finnigan W, Lubberink M, Hepworth L, Citoler J, Mattey A, Ford G, et al.
ACS Catal
. 2023 Sep;
13(17):11771-11780.
PMID: 37671181
Despite the increasing use of biocatalysis for organic synthesis, there are currently no databases that adequately capture synthetic biotransformations. The lack of a biocatalysis database prevents accelerating biocatalyst characterization efforts...
3.
Dennis J, Johnson N, Thorpe T, Wallace S
Angew Chem Int Ed Engl
. 2023 Jul;
62(38):e202306347.
PMID: 37477977
Small molecule organocatalysts are abundant in all living organisms. However, their use as organocatalysts in cells has been underexplored. Herein, we report that organocatalytic aldol chemistry can be interfaced with...
4.
Gilio A, Thorpe T, Heyam A, Petchey M, Pogranyi B, France S, et al.
ACS Catal
. 2023 Feb;
13(3):1669-1677.
PMID: 36776386
Imine reductases (IREDs) catalyze the asymmetric reduction of cyclic imines, but also in some cases the coupling of ketones and amines to form secondary amine products in an enzyme-catalyzed reductive...
5.
Harawa V, Thorpe T, Marshall J, Sangster J, Gilio A, Pirvu L, et al.
J Am Chem Soc
. 2022 Nov;
144(46):21088-21095.
PMID: 36350999
The development of efficient and sustainable methods for the synthesis of nitrogen heterocycles is an important goal for the chemical industry. In particular, substituted chiral piperidines are prominent targets due...
6.
Gilio A, Thorpe T, Turner N, Grogan G
Chem Sci
. 2022 Jun;
13(17):4697-4713.
PMID: 35655886
The synthesis of secondary and tertiary amines through the reductive amination of carbonyl compounds is one of the most significant reactions in synthetic chemistry. Asymmetric reductive amination for the formation...
7.
Thorpe T, Marshall J, Harawa V, Ruscoe R, Cuetos A, Finnigan J, et al.
Nature
. 2022 Apr;
604(7904):86-91.
PMID: 35388195
Chiral amine diastereomers are ubiquitous in pharmaceuticals and agrochemicals, yet their preparation often relies on low-efficiency multi-step synthesis. These valuable compounds must be manufactured asymmetrically, as their biochemical properties can...
8.
Burke A, Birmingham W, Zhuo Y, Thorpe T, Zucoloto da Costa B, Crawshaw R, et al.
J Am Chem Soc
. 2022 Feb;
144(9):3761-3765.
PMID: 35224970
The Covid-19 pandemic highlights the urgent need for cost-effective processes to rapidly manufacture antiviral drugs at scale. Here we report a concise biocatalytic process for Molnupiravir, a nucleoside analogue recently...
9.
Mangas-Sanchez J, Sharma M, Cosgrove S, Ramsden J, Marshall J, Thorpe T, et al.
Chem Sci
. 2021 Jun;
11(19):5052-5057.
PMID: 34122962
Chiral primary amines are important intermediates in the synthesis of pharmaceutical compounds. Fungal reductive aminases (RedAms) are NADPH-dependent dehydrogenases that catalyse reductive amination of a range of ketones with short-chain...
10.
Marshall J, Yao P, Montgomery S, Finnigan J, Thorpe T, Palmer R, et al.
Nat Chem
. 2020 Dec;
13(2):140-148.
PMID: 33380742
Finding faster and simpler ways to screen protein sequence space to enable the identification of new biocatalysts for asymmetric synthesis remains both a challenge and a rate-limiting step in enzyme...