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Thomas S Denney Jr

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Citations 531
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Recent Articles
1.
Aufan M, Gupta H, Sharifov O, Perry G, Denney Jr T, Lloyd S
J Cardiovasc Magn Reson . 2024 Nov; 26(2):101122. PMID: 39510416
Background: Left ventricular (LV) diastolic function is a key determinant of cardiac output and impairments of diastolic function can lead to heart failure. Assessment of diastolic function is challenging due...
2.
Zheng J, Huang S, Ahmed M, Pat B, Lloyd S, Sharifov O, et al.
Front Cardiovasc Med . 2024 Oct; 11:1410859. PMID: 39469127
Background: 2020 American College of Cardiology/American Heart Association (ACC/AHA) Guidelines state that the ideal time for mitral valve surgery in primary mitral regurgitation (PMR) is when the LV approaches but...
3.
Deshpande G, Zhao S, Waggoner P, Beyers R, Morrison E, Huynh N, et al.
Animals (Basel) . 2024 Apr; 14(7). PMID: 38612321
Functional brain connectivity based on resting-state functional magnetic resonance imaging (fMRI) has been shown to be correlated with human personality and behavior. In this study, we sought to know whether...
4.
Sharifov O, Denney Jr T, Girard A, Gupta H, Lloyd S
Int J Cardiol . 2023 May; 387:131102. PMID: 37257514
Background: Left atrial (LA) strain is impaired in left ventricular (LV) diastolic dysfunction, associated with increased LV end diastolic pressure (LVEDP). In patients with preserved LV ejection fraction (LVEF), coronary...
5.
Aufan M, Jost Z, Miller N, Sharifov O, Gupta H, Perry G, et al.
Cardiovasc Eng Technol . 2023 Mar; 14(3):447-456. PMID: 36971975
Purpose: Knowledge of the timing of cardiac valve opening and closing is important in cardiac physiology. The relationship between valve motion and electrocardiogram (ECG) is often assumed, however is not...
6.
Kaddoumi A, Denney Jr T, Deshpande G, Robinson J, Beyers R, Redden D, et al.
Nutrients . 2022 Dec; 14(23). PMID: 36501136
Mild cognitive impairment (MCI) and early Alzheimer's disease (AD) are characterized by blood-brain barrier (BBB) breakdown leading to abnormal BBB permeability ahead of brain atrophy or dementia. Previous findings in...
7.
Ahmed M, Andrikopoulou E, Zheng J, Ulasova E, Pat B, Kelley E, et al.
JACC Basic Transl Sci . 2022 Nov; 7(10):973-981. PMID: 36337921
Interstitial collagen loss and cardiomyocyte ultrastructural damage accounts for left ventricular (LV) sphericity and decrease in LV twist and circumferential strain. Normal LV diastolic function belies significantly abnormal left atrial...
8.
Butts B, Brown J, Denney Jr T, Ballinger S, Lloyd S, Oparil S, et al.
Hypertension . 2022 Feb; 79(4):775-784. PMID: 35164526
Background: We previously reported increased plasma XO (xanthine oxidase) activity in patients with resistant hypertension. Increased XO can cause mitochondrial DNA damage and promote release of fragments called mitochondrial DNA...
9.
Gamble F, Aufan M, Sharifov O, Williams L, Reighard S, Calhoun D, et al.
Physiol Meas . 2022 Jan; 43(2). PMID: 35073533
We developed a method using cardiovascular magnetic resonance imaging to model the untwisting of the left ventricle (LV) as a damped torsional harmonic oscillator to estimate shear modulus (intrinsic myocardial...
10.
Aryal S, Siddiqui M, Sharifov O, Coffin M, Zhang B, Gaddam K, et al.
J Am Heart Assoc . 2021 Aug; 10(17):e019434. PMID: 34459249
Background Aortic stiffness is an independent predictor of cardiovascular events in patients with arterial hypertension. Resistant hypertension is often linked to hyperaldosteronism and associated with adverse outcomes. Spironolactone, a mineralocorticoid...