Thomas R Kosten
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Explore the profile of Thomas R Kosten including associated specialties, affiliations and a list of published articles.
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329
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Recent Articles
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Kosten T, Koirala A, Nielsen D, Domingo C, Thomas Y, Gunaratne P, et al.
Vaccines (Basel)
. 2025 Feb;
13(2).
PMID: 40006728
: Cocaine and illicit amphetamines (disguised as "Adderall") are being laced with fentanyl and producing accidental and intentional fatal overdoses. Vaccines can prevent these overdoses, but 33% of humans generate...
3.
Fava M, Pani L, De Martin S, Cutler A, Gorodetzky C, Vocci F, et al.
J Clin Psychiatry
. 2025 Feb;
86(1).
PMID: 39999772
Esmethadone is a novel -methyl-D-aspartate receptor (NMDAR) uncompetitive antagonist in development as adjunctive treatment for major depressive disorder (MDD). This 12-month, open-label study evaluated the safety and efficacy of esmethadone...
4.
Miranda O, Qi X, Brannock M, Whitworth R, Kosten T, Ryan N, et al.
Biomedicines
. 2025 Jan;
12(12.
PMID: 39767679
Comorbid post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) patients are at a significantly higher risk of adverse outcomes, including opioid use disorder, depression, suicidal behaviors, and death, yet...
5.
Zhou D, Li X, Wei S, Yu C, Wang D, Li Y, et al.
JAMA Netw Open
. 2024 Nov;
7(11):e2444306.
PMID: 39535797
Importance: Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are both recognized as effective treatments for depression when applied individually. However, it is unknown whether rTMS combined...
6.
Bigdeli T, Chatzinakos C, Bendl J, Barr P, Venkatesh S, Gorman B, et al.
medRxiv
. 2024 Sep;
PMID: 39252912
Large-scale genome-wide association studies of schizophrenia have uncovered hundreds of associated loci but with extremely limited representation of African diaspora populations. We surveyed electronic health records of 200,000 individuals of...
7.
Petrakis I, Nolen T, Vandergrift N, Hirsch S, Krystal J, De Vivo M, et al.
Am J Addict
. 2024 Aug;
34(1):7-14.
PMID: 39152094
Background And Objectives: Noradrenergic dysregulation is important in the pathophysiology of posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD); pharmacotherapies targeting adrenergic function have potential as treatment for comorbidity....
8.
Wilkinson A, Chen B, Swann A, Graham D, Nielsen D, Kosten T, et al.
Nicotine Tob Res
. 2024 Jul;
27(1):54-60.
PMID: 39028574
Introduction: Cigarette use and smoking intensity increase risk of suicidal ideation. Less is known about e-cigarette use. Here we examine direct influences of cigarette versus e-cigarette use on suicidal ideation...
9.
Wang D, Tian Y, Chen J, Zhu R, Li J, Zhou H, et al.
Curr Neuropharmacol
. 2024 Jun;
22(14):2443-2452.
PMID: 38919004
Background: Excessive free radicals are implicated in the pathophysiology of tardive dyskinesia (TD), and extract (EGb761) scavenges free radicals, thereby enhancing antioxidant enzymes such as mitochondrial manganese superoxide dismutase (MnSOD)....
10.
Fava M, Stahl S, Pani L, De Martin S, Cutler A, Maletic V, et al.
J Clin Psychiatry
. 2024 Jun;
85(3).
PMID: 38917366
To test esmethadone (REL-1017) as adjunctive treatment in patients with major depressive disorder (MDD) and inadequate response to standard antidepressants. In this phase 3, double-blind, placebo-controlled trial, outpatients with MDD...