Thomas M H Lee
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Explore the profile of Thomas M H Lee including associated specialties, affiliations and a list of published articles.
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13
Citations
110
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Recent Articles
1.
Wang S, Qin A, Chau L, Fok E, Choy M, Brackman C, et al.
ACS Appl Mater Interfaces
. 2022 Jul;
14(31):35299-35308.
PMID: 35895859
Loop-mediated isothermal amplification (LAMP) has received considerable attention for decentralized (point-of-care and on-site) nucleic acid testing in view of its simple temperature control (60-65 °C) and short assay time (15-60...
2.
Gedefaw L, Ullah S, Lee T, Yip S, Huang C
Biomedicines
. 2021 Dec;
9(12).
PMID: 34944639
Mortality and morbidity associated with COVID-19 continue to be significantly high worldwide, owing to the absence of effective treatment strategies. The emergence of different variants of SARS-CoV-2 is also a...
3.
Meng F, Siu G, Mok B, Sun J, Fung K, Lam J, et al.
Cells
. 2021 Aug;
10(7).
PMID: 34359932
MicroRNAs (miRNAs) are critical regulators of gene expression that may be used to identify the pathological pathways influenced by disease and cellular interactions. Viral miRNAs (v-miRNAs) encoded by both DNA...
4.
Chau L, He Q, Qin A, Yip S, Lee T
J Mater Chem B
. 2020 Apr;
4(23):4076-4083.
PMID: 32264609
In this work, we developed a simple and sensitive colorimetric detection platform for specific DNA sequences by using peroxidase mimetics of platinum nanoparticles supported on reduced graphene oxide. This nanocomposite...
5.
Qin A, Fu L, Wong J, Chau L, Yip S, Lee T
ACS Appl Mater Interfaces
. 2017 Mar;
9(12):10472-10480.
PMID: 28276674
Gold nanoparticles have proven to be promising for decentralized nucleic acid testing by virtue of their simple visual readout and absorbance-based quantification. A major challenge toward their practical application is...
6.
7.
Wong J, Yip S, Lee T
Small
. 2011 Nov;
8(2):214-9.
PMID: 22095584
A facile silica coating significantly enhances the thermal stability and polymerase chain reaction (PCR) compatibility of oligonucleotide-gold nanoparticle conjugates, thus enabling colorimetric detection of PCR results in a closed-tube format....
8.
Yeung S, Lee T, Hsing I
Anal Chem
. 2007 Dec;
80(2):363-8.
PMID: 18088101
The development of handheld instruments for point-of-care DNA analysis can potentially contribute to the medical diagnostics and environmental monitoring for decentralized applications. In this work, we demonstrate the implementation of...
9.
Zhao W, Lee T, Leung S, Hsing I
Langmuir
. 2007 May;
23(13):7143-7.
PMID: 17518486
Gold nanoparticles are one of the popular nanomaterials, widely used in biosensor applications as well as nanostructure construction. An essential attribute of these gold nanoparticles (Au-nps) is their stabilization against...
10.
Yeung S, Lee T, Hsing I
J Am Chem Soc
. 2006 Oct;
128(41):13374-5.
PMID: 17031947
In this work, we report the first electrochemistry-based real-time polymerase chain reaction technique for sequence-specific nucleic acid detection. This new technique builds upon the advantages of the well-established fluorescence-based counterpart,...