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Thomas Loudovaris

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Articles 48
Citations 1230
Followers 0
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Recent Articles
1.
Germanos M, Yau B, Taper M, Yeoman C, Wilson A, An Y, et al.
iScience . 2025 Feb; 28(2):111719. PMID: 39898024
In type 2 diabetes (T2D), the rate of insulin secretory granule biogenesis can limit insulin secretion from pancreatic β-cells. Using rat insulinoma INS1 β-cells, we show that the soluble Ca-binding/trafficking...
2.
Norris N, Yau B, Famularo C, Webster H, Loudovaris T, Thomas H, et al.
Diabetes . 2024 Sep; 73(12):2045-2054. PMID: 39320956
Article Highlights:
3.
Jevon D, Cottle L, Hallahan N, Harwood R, Samra J, Gill A, et al.
Diabetologia . 2024 May; 67(8):1683-1697. PMID: 38814445
Aims/hypothesis: Almost all beta cells contact one capillary and insulin granule fusion is targeted to this region. However, there are reports of beta cells contacting more than one capillary. We...
4.
Al-Hasani K, Marikar S, Kaipananickal H, Maxwell S, Okabe J, Khurana I, et al.
Signal Transduct Target Ther . 2023 Dec; 9(1):2. PMID: 38161208
β-cells are a type of endocrine cell found in pancreatic islets that synthesize, store and release insulin. In type 1 diabetes (T1D), T-cells of the immune system selectively destroy the...
5.
Mangiafico S, Tuo Q, Li X, Liu Y, Haralambous C, Ding X, et al.
Mol Psychiatry . 2023 Sep; 28(9):3982-3993. PMID: 37735502
Tau protein is implicated in the pathogenesis of Alzheimer's disease (AD) and other tauopathies, but its physiological function is in debate. Mostly explored in the brain, tau is also expressed...
6.
Rojas-Canales D, Walters S, Penko D, Cultrone D, Bailey J, Chtanova T, et al.
Diabetes . 2023 Mar; 72(6):758-768. PMID: 36929171
Article Highlights: Human and porcine pancreatic islets were transplanted into a fully vascularized biodegradable temporizing matrix (Novosorb) that creates a unique intracutaneous site outside of the liver in a large-animal...
7.
Donaldson L, McAuley S, Goodman D, Howe K, Loudovaris T, MacIsaac R, et al.
Intern Med J . 2023 Feb; 53(2):293-295. PMID: 36822610
No abstract available.
8.
Myo Min K, Rojas-Canales D, Penko D, DeNichilo M, Cockshell M, Ffrench C, et al.
Cell Death Dis . 2022 Oct; 13(10):911. PMID: 36309486
Type 1 diabetes is a complex disease characterized by the lack of endogenous insulin secreted from the pancreatic β-cells. Although β-cell targeted autoimmune processes and β-cell dysfunction are known to...
9.
Al-Hasani K, Khurana I, Mariana L, Loudovaris T, Maxwell S, Harikrishnan K, et al.
Signal Transduct Target Ther . 2022 Jul; 7(1):248. PMID: 35864094
Type 1 diabetes (T1D) is an autoimmune disease that selectively destroys insulin-producing β-cells in the pancreas. An unmet need in diabetes management, current therapy is focussed on transplantation. While the...
10.
Koneshamoorthy A, Seniveratne-Epa D, Calder G, Sawyer M, Kay T, Farrell S, et al.
Front Endocrinol (Lausanne) . 2022 Apr; 13:842937. PMID: 35370948
We present a case of an obese 22-year-old man with activating variant who had neonatal hypoglycemia, re-emerging with hypoglycemia later in life. We investigated him for asymptomatic hypoglycemia with a...