Thomas Klein
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Explore the profile of Thomas Klein including associated specialties, affiliations and a list of published articles.
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Articles
266
Citations
4483
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Recent Articles
1.
Vullings N, Airich A, Seib E, Troost T, Klein T
BMC Biol
. 2025 Mar;
23(1):71.
PMID: 40050848
Background: Notch signalling plays a crucial role in many developmental, homoeostatic and pathological processes in metazoans. The pathway is activated by binding of the ligand to the Notch receptor, which...
2.
Saleem M, Zafar S, Klein T, Koesters M, Bashir A, Fuhr D, et al.
JMIR Form Res
. 2025 Jan;
9:e59414.
PMID: 39874072
Background: Mental health remains among the top 10 leading causes of disease burden globally, and there is a significant treatment gap due to limited resources, stigma, limited accessibility, and low...
3.
Delic D, Klein T, Wohnhaas C, Feng H, Lin X, Zhang J, et al.
Biomed Pharmacother
. 2024 Dec;
182():117778.
PMID: 39724680
Background: Excessive inflammation in sepsis causes microvascular dysfunction associated with organ dysfunction and high mortality. The present studies aimed to examine the therapeutic potential of linagliptin, a dipeptidyl peptidase-4 (DPP-4)...
4.
Chen X, Delic D, Liu Y, Cao Y, Zhang Z, Wu H, et al.
Basic Clin Pharmacol Toxicol
. 2024 Nov;
136(1):e14103.
PMID: 39520247
Renal fibrosis is closely related to the prognosis of chronic kidney disease (CKD). The increase in cGMP reduces renal fibrosis. Soluble guanylate cyclase (sGC) and phosphodiesterase (PDE) are key enzymes...
5.
Chen X, Xiong Y, Zeng S, Delic D, Gaballa M, Kalk P, et al.
Front Pharmacol
. 2024 Nov;
15:1480186.
PMID: 39494352
Introduction: Soluble guanylate cyclase (sGC) stimulators and activators are known to enhance kidney function in various models of chronic kidney disease (CKD) by increasing cyclic guanosine monophosphate (cGMP). Their differential...
6.
Vincendeau M, Klein T, Groubatch F, Tran N, Kimmoun A, Levy B
Intensive Care Med Exp
. 2024 Aug;
12(1):74.
PMID: 39190241
Background: Acute respiratory distress syndrome (ARDS) remains a significant challenge in critical care, with high mortality rates despite advancements in treatment. Venovenous extracorporeal membrane oxygenation (VV-ECMO) is employed as salvage...
7.
Bougouin W, Lascarrou J, Chelly J, Benghanem S, Geri G, Maizel J, et al.
Resuscitation
. 2024 Aug;
202():110362.
PMID: 39151721
Aim: To investigate the performance of the 2021 ERC/ESICM-recommended algorithm for predicting poor outcome after cardiac arrest (CA) and potential tools for predicting neurological recovery in patients with indeterminate outcome....
8.
Cao R, Gozlan O, Airich A, Tveriakhina L, Zhou H, Jiang H, et al.
Structure
. 2024 Aug;
32(10):1667-1676.e5.
PMID: 39121852
Mind bomb 1 (MIB1) is a RING E3 ligase that ubiquitinates Notch ligands, a necessary step for induction of Notch signaling. The structural basis for binding of the JAG1 ligand...
9.
Breuer T, Tibbe C, Troost T, Klein T
Cells
. 2024 Jul;
13(14.
PMID: 39056756
Members of the LGD/CC2D1 protein family contain repeats of the family-defining DM14 domains. Via this domain, they interact with members of the CHMP family, which are essential for the ESCRT...
10.
Klein T, Breilmann J, Schneider C, Girlanda F, Fiedler I, Dawson S, et al.
J Consult Clin Psychol
. 2024 Jun;
92(5):296-309.
PMID: 38829329
Objective: Evidence on the optimal "dose" of cognitive behavioral therapy (CBT) for treating major depressive disorder is sparse. This analysis aimed to evaluate the dose-response curve in CBT using a...