Thomas Jacob
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Explore the profile of Thomas Jacob including associated specialties, affiliations and a list of published articles.
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26
Citations
469
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Recent Articles
11.
Burwitz B, Wettengel J, Muck-Hausl M, Ringelhan M, Ko C, Festag M, et al.
Nat Commun
. 2017 Dec;
8(1):2146.
PMID: 29247188
Hepatitis B virus (HBV) is a major global health concern, and the development of curative therapeutics is urgently needed. Such efforts are impeded by the lack of a physiologically relevant,...
12.
Jacob T, Gray J, Troxell M, Vu T
Breast Cancer Res Treat
. 2016 Sep;
159(3):575-83.
PMID: 27581127
Purpose: Activating genetic changes in the phosphatidylinositol-3-kinase (PI3K) signaling pathway are found in over half of invasive breast cancers (IBCs). Previously, we discovered numerous hotspot PIK3CA mutations in proliferative breast...
13.
Jacob T, Agarwal A, Ramunno-Johnson D, OHare T, Gonen M, Tyner J, et al.
Sci Rep
. 2016 Jun;
6:28163.
PMID: 27320899
Many important signaling and regulatory proteins are expressed at low abundance and are difficult to measure in single cells. We report a molecular imaging approach to quantitate protein levels by...
14.
Vermehren-Schmaedick A, Krueger W, Jacob T, Ramunno-Johnson D, Balkowiec A, Lidke K, et al.
PLoS One
. 2014 Apr;
9(4):e95113.
PMID: 24732948
Accumulating evidence underscores the importance of ligand-receptor dynamics in shaping cellular signaling. In the nervous system, growth factor-activated Trk receptor trafficking serves to convey biochemical signaling that underlies fundamental neural...
15.
Jacob T, Wahr J, Pfeffer W, Swenson S
Nature
. 2012 Feb;
482(7386):514-8.
PMID: 22318519
Glaciers and ice caps (GICs) are important contributors to present-day global mean sea level rise. Most previous global mass balance estimates for GICs rely on extrapolation of sparse mass balance...
16.
Mittoo S, Jacob T, Craig A, Bshouty Z
Can Respir J
. 2010 Dec;
17(6):282-6.
PMID: 21165350
Background: Pulmonary hypertension (PH) in patients with connective tissue disease (CTD) can occur in isolation or concomitantly with interstitial lung disease (ILD). Targeted therapies for PH can mitigate clinical deterioration...
17.
Rasanen J, Girsen A, Lu X, Lapidus J, Standley M, Reddy A, et al.
J Proteome Res
. 2010 Jun;
9(8):4274-81.
PMID: 20568817
We systematically characterized maternal serum proteome in women with clinical preeclampsia (PE) and asymptomatic women in early pregnancy that subsequently developed PE. Clinical PE cohort comprised 30 patients with mild...
18.
Hitti J, Lapidus J, Lu X, Reddy A, Jacob T, Dasari S, et al.
Am J Obstet Gynecol
. 2010 May;
203(1):32.e1-8.
PMID: 20478552
Objective: We analyzed the vaginal fluid proteome to identify biomarkers of intraamniotic infection among women in preterm labor. Study Design: Proteome analysis was performed on vaginal fluid specimens from women...
19.
Magill P, Jacob T, Lennon G
Urology
. 2007 May;
69(5):983.e7-8.
PMID: 17482955
Segmental testicular infarction is a very rare entity. We present a case in a patient with prior retroperitoneal surgery who developed segmental infarction after routine vasectomy.
20.
Michaels J, Dasari S, Pereira L, Reddy A, Lapidus J, Lu X, et al.
J Proteome Res
. 2007 Mar;
6(4):1277-85.
PMID: 17373841
Amniotic fluid (AF) is a significant contributor to fetal health and constitutes a potential rich source of biomarkers for diagnosis of maternal and fetal disorders. In this study, we performed...