Thomas J Sharpton
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Explore the profile of Thomas J Sharpton including associated specialties, affiliations and a list of published articles.
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88
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2513
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Recent Articles
1.
Alexiev A, Stretch E, Kasschau K, Wilson L, Truong L, Tanguay R, et al.
Toxics
. 2025 Jan;
13(1).
PMID: 39853010
Developmental exposure to benzo[a]pyrene (BaP), a ubiquitous environmental pollutant, has been linked to various toxic effects, including multigenerational behavioral impairment. While the specific mechanisms driving BaP neurotoxicity are not fully...
2.
Hammer A, Gaulke C, Garcia-Jaramillo M, Leong C, Morre J, Sieler Jr M, et al.
mSystems
. 2024 Aug;
9(9):e0054524.
PMID: 39191377
Importance: Intestinal helminth parasites (IHPs) impact human health globally and interfere with animal health and agricultural productivity. While anthelmintics are critical to controlling parasite infections, their efficacy is increasingly compromised...
3.
Hammer A, Gaulke C, Garcia-Jaramillo M, Leong C, Morre J, Sieler M, et al.
bioRxiv
. 2024 Aug;
PMID: 39091873
Intestinal helminth parasite (IHP) infection induces alterations in the composition of microbial communities across vertebrates, although how gut microbiota may facilitate or hinder parasite infection remains poorly defined. In this...
4.
Stagaman K, Alexiev A, Sieler M, Hammer A, Kasschau K, Truong L, et al.
Sci Rep
. 2024 Jun;
14(1):14618.
PMID: 38918492
Early-life exposure to environmental toxicants like Benzo[a]pyrene (BaP) is associated with several health consequences in vertebrates (i.e., impaired or altered neurophysiological and behavioral development). Although toxicant impacts were initially studied...
5.
Sharpton T, Alexiev A, Tanguay R
Curr Opin Toxicol
. 2024 Mar;
36.
PMID: 38486798
The gut microbiome, critical to maintaining vertebrate homeostasis, is susceptible to a various exposures. In some cases, these exposures induce dysbiosis, wherein the microbiome changes into a state conducive to...
6.
Jamieson P, Smart E, Bouranis J, Choi J, Danczak R, Wong C, et al.
Gut Microbes
. 2024 Feb;
16(1):2315633.
PMID: 38358253
Xanthohumol (XN), a polyphenol found in the hop plant (), has antioxidant, anti-inflammatory, prebiotic, and anti-hyperlipidemic activity. Preclinical evidence suggests the gut microbiome is essential in mediating these bioactivities; however,...
7.
Vompe A, Epstein H, Speare K, Schmeltzer E, Adam T, Burkepile D, et al.
Glob Chang Biol
. 2024 Jan;
30(1):e17088.
PMID: 38273492
Microbiomes are essential features of holobionts, providing their hosts with key metabolic and functional traits like resistance to environmental disturbances and diseases. In scleractinian corals, questions remain about the microbiome's...
8.
Bouranis J, Beaver L, Wong C, Choi J, Hamer S, Davis E, et al.
Mol Nutr Food Res
. 2023 Dec;
68(4):e2300286.
PMID: 38143283
Scope: The glucosinolate glucoraphanin from broccoli is converted to sulforaphane (SFN) or sulforaphane-nitrile (SFN-NIT) by plant enzymes or the gut microbiome. Human feeding studies typically observe high inter-individual variation in...
9.
Sharpton T, Lu Y, Kent M, Watts S, Varga Z
Zebrafish
. 2023 Dec;
20(6):243-249.
PMID: 38117219
Progress in biomedical research requires rigorous studies and reproducible outcomes. However, despite recent achievements, standard reference diets (SRDs) for aquatic model organisms, vital for supporting scientific rigor and reproducibility, are...
10.
Singleton S, Davis 2nd E, Arnold H, Daniels A, Brander S, Parsons R, et al.
Front Microbiol
. 2023 Oct;
14:1259014.
PMID: 37869676
Plastic waste accumulation in marine environments has complex, unintended impacts on ecology that cross levels of community organization. To measure succession in polyolefin-colonizing marine bacterial communities, an time-series experiment was...