Thomas J Cirino
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Explore the profile of Thomas J Cirino including associated specialties, affiliations and a list of published articles.
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13
Citations
154
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Recent Articles
1.
Hammond H, Eans S, Cirino T, Ananthan S, Jimenez-Torres A, Zhu J, et al.
NeuroImmune Pharm Ther
. 2024 May;
3(1):1-6.
PMID: 38711842
Objectives: HIV-1 Tat (transactivator of transcription) protein disrupts dopaminergic transmission and potentiates the rewarding effects of cocaine. Allosteric modulators of the dopamine transporter (DAT) have been shown to reverse Tat-induced...
2.
Zhu J, Quizon P, Wang Y, Adeniran C, Strauss M, Jimenez-Torres A, et al.
Neuropharmacology
. 2022 Sep;
220:109239.
PMID: 36126727
Cocaine abuse increases the incidence of HIV-1-associated neurocognitive disorders. We have demonstrated that HIV-1 transactivator of transcription (Tat) allosterically modulates dopamine (DA) reuptake through the human DA transporter (hDAT), potentially...
3.
Wilson L, Alleyne A, Eans S, Cirino T, Stacy H, Mottinelli M, et al.
Molecules
. 2022 Jun;
27(11).
PMID: 35684553
Sigma receptors modulate nociception, offering a potential therapeutic target to treat pain, but relatively little is known regarding the role of sigma-2 receptors (S2R) in nociception. The purpose of this...
4.
Waung M, Maanum K, Cirino T, Driscoll J, OBrien C, Bryant S, et al.
Nat Commun
. 2022 Feb;
13(1):764.
PMID: 35140231
Mu opioid receptor (MOR) agonists are potent analgesics, but also cause sedation, respiratory depression, and addiction risk. The epithalamic lateral habenula (LHb) signals aversive states including pain, and here we...
5.
Zhang P, Guergues J, Alleyne A, Cirino T, Nadeau O, Figueroa A, et al.
Proteomics
. 2022 Jan;
22(9):e2100137.
PMID: 35081661
As the resident immune cells in the central nervous system, microglia play an important role in the maintenance of its homeostasis. Dysregulation of microglia has been associated with the development...
6.
Mini review: Promotion of substance abuse in HIV patients: Biological mediation by HIV-1 Tat protein
Cirino T, McLaughlin J
Neurosci Lett
. 2021 Apr;
753:135877.
PMID: 33838257
Despite successful viral suppression by combinatorial anti-retroviral therapy, HIV infection continues to negatively impact the quality of life of patients by promoting neuropathy and HIV-Associated Neurocognitive Disorders (HAND), where substance...
7.
Cirino T, Alleyne A, Duarte V, Figueroa A, Simons C, Anceaume E, et al.
J Neuroimmune Pharmacol
. 2021 Feb;
17(1-2):152-164.
PMID: 33619645
Despite the success of combined antiretroviral therapy (cART) in reducing viral load, a substantial portion of Human Immunodeficiency Virus (HIV)+ patients report chronic pain. The exact mechanism underlying this co-morbidity...
8.
Wilson L, Chakraborty S, Eans S, Cirino T, Stacy H, Simons C, et al.
Cell Mol Neurobiol
. 2021 Jan;
41(5):1131-1143.
PMID: 33433723
Chronic administration of opioids produces physical dependence and opioid-induced hyperalgesia. Users claim the Thai traditional tea "kratom" and component alkaloid mitragynine ameliorate opioid withdrawal without increased sensitivity to pain. Testing...
9.
Wilson L, Harris H, Eans S, Brice-Tutt A, Cirino T, Stacy H, et al.
Drug Alcohol Depend
. 2020 Oct;
216:108310.
PMID: 33017752
Background: Made as a tea, the Thai traditional drug "kratom" reportedly possesses pharmacological actions that include both a coca-like stimulant effect and opium-like depressant effect. Kratom has been used as...
10.
Sivalingam K, Cirino T, McLaughlin J, Samikkannu T
Mol Neurobiol
. 2020 Sep;
58(2):490-504.
PMID: 32978730
HIV infection and drugs of abuse induce oxidative stress and redox imbalance, which cause neurodegeneration. The mechanisms by which HIV infection and cocaine consumption affect astrocyte energy metabolism, and how...