Thomas H Tugwell
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Explore the profile of Thomas H Tugwell including associated specialties, affiliations and a list of published articles.
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4
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7
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Recent Articles
1.
Chen M, Knox C, Madhusudhanan M, Tugwell T, Liu C, Liu P, et al.
Nature
. 2024 May;
631(8020):328-334.
PMID: 38782036
Concerted nucleophilic substitution, known as S2 reaction, is a fundamental organic transformation used in synthesis to introduce new functional groups and construct carbon-carbon and carbon-heteroatom bonds. S2 reactions typically involve...
2.
Lyu H, Tugwell T, Chen Z, Kukier G, Turlik A, Wu Y, et al.
Nat Chem
. 2023 Oct;
16(2):269-276.
PMID: 37783725
1,2-Azaborines represent a unique class of benzene isosteres that have attracted interest for developing pharmaceuticals with better potency and bioavailability. However, it remains a long-standing challenge to prepare monocyclic 1,2-azaborines,...
3.
Stepherson J, Ayala C, Tugwell T, Henry J, Fronczek F, Kartika R
Org Lett
. 2016 Jun;
18(12):3002-5.
PMID: 27265237
We report a new strategy toward the synthesis of highly functionalized carbazoles via 2-(silyloxy)pentadienyl cation intermediates, which were generated upon ionization of vinyl-substituted α-hydroxy silyl enol ethers under Brønsted acid...
4.
Villalpando A, Saputra M, Tugwell T, Kartika R
Chem Commun (Camb)
. 2015 Sep;
51(81):15075-8.
PMID: 26323232
We describe a strategy to chlorinate stereocomplementary acyclic aliphatic 1,3-diols using a mixture of triphosgene and pyridine. While 1,3-anti diols readily led to 1,3-anti dichlorides, 1,3-syn diols must be converted...