Thomas E Kehl-Fie
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Explore the profile of Thomas E Kehl-Fie including associated specialties, affiliations and a list of published articles.
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2701
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Recent Articles
1.
Hossain S, Morey J, Neville S, Ganio K, Radin J, Norambuena J, et al.
mBio
. 2023 Sep;
14(5):e0135023.
PMID: 37737591
During infection, bacteria must overcome the dual threats of metal starvation and intoxication. This work reveals that the zinc-withholding response of the host sensitizes to copper intoxication. In response to...
2.
Price S, Thibault D, Garrison T, Brady A, Guo H, Kehl-Fie T, et al.
EMBO Rep
. 2023 Jul;
24(10):e57369.
PMID: 37501563
Nutritional immunity includes sequestration of transition metals from invading pathogens. Yersinia pestis overcomes nutritional immunity by secreting yersiniabactin to acquire iron and zinc during infection. While the mechanisms for yersiniabactin...
3.
Hossain S, Morey J, Neville S, Ganio K, Radin J, Norambuena J, et al.
bioRxiv
. 2023 Jul;
PMID: 37398167
Importance: During infection bacteria must overcome the dual threats of metal starvation and intoxication. This work reveals that the zinc-withholding response of the host sensitizes to copper intoxication. In response...
4.
Akbari M, Keogh R, Radin J, Sanchez-Rosario Y, Johnson M, Horswill A, et al.
mBio
. 2023 Jun;
14(4):e0030423.
PMID: 37358277
Group B (GBS) is a Gram-positive pathobiont that can cause adverse health outcomes in neonates and vulnerable adult populations. GBS is one of the most frequently isolated bacteria from diabetic...
5.
Padron G, Shuppara A, Sharma A, Koch M, Palalay J, Radin J, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(11):e2216774120.
PMID: 36888662
Cells regularly experience fluid flow in natural systems. However, most experimental systems rely on batch cell culture and fail to consider the effect of flow-driven dynamics on cell physiology. Using...
6.
Parraga Solorzano P, Bastille T, Radin J, Kehl-Fie T
mBio
. 2023 Jan;
14(1):e0322322.
PMID: 36598285
The preferred carbon source of Staphylococcus aureus and many other pathogens is glucose, and its consumption is critical during infection. However, glucose utilization increases the cellular demand for manganese, a...
7.
Charbonnier M, Gonzalez-Espinoza G, Kehl-Fie T, Lalaouna D
Front Cell Infect Microbiol
. 2022 Jul;
12:952948.
PMID: 35865816
Metal such as iron, zinc, manganese, and nickel are essential elements for bacteria. These nutrients are required in crucial structural and catalytic roles in biological processes, including precursor biosynthesis, DNA...
8.
Burcham L, Akbari M, Alhajjar N, Keogh R, Radin J, Kehl-Fie T, et al.
mBio
. 2022 Jun;
13(3):e0098522.
PMID: 35658538
Group B Streptococcus (GBS) is associated with severe infections and in newborn populations, including pneumonia, sepsis, and meningitis. GBS vaginal colonization of the pregnant mother is an important prerequisite for...
9.
Frye K, Sendra K, Waldron K, Kehl-Fie T
J Inorg Biochem
. 2022 Feb;
230:111748.
PMID: 35151099
Superoxide dismutases (SODs) are ancient enzymes of widespread importance present in all domains of life. Many insights have been gained into these important enzymes over the 50 years since their...
10.
Price S, Vadyvaloo V, DeMarco J, Brady A, Gray P, Kehl-Fie T, et al.
Proc Natl Acad Sci U S A
. 2021 Oct;
118(44).
PMID: 34716262
causes human plague and colonizes both a mammalian host and a flea vector during its transmission cycle. A key barrier to bacterial infection is the host's ability to actively sequester...