Thomas D Als
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Explore the profile of Thomas D Als including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
OConnell K, Koromina M, van der Veen T, Boltz T, David F, Yang J, et al.
Nature
. 2025 Jan;
PMID: 39843750
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants...
2.
Mundy J, Hall A, Steinbach J, Albinana C, Agerbo E, Als T, et al.
Psychol Med
. 2024 Oct;
:1-10.
PMID: 39397681
Background: The clinical course of major depressive disorder (MDD) is heterogeneous, and early-onset MDD often has a more severe and complex clinical course. Our goal was to determine whether polygenic...
3.
Pisanu C, Congiu D, Meloni A, Paribello P, Severino G, Ardau R, et al.
Psychiatry Res
. 2024 Sep;
342:116195.
PMID: 39299147
High rates of metabolic risk factors contribute to premature mortality in patients with severe mental disorders, but the molecular underpinnings of this association are largely unknown. We performed the first...
4.
Bergstedt J, Pasman J, Ma Z, Harder A, Yao S, Parker N, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(6):754-769.
PMID: 39215135
Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with...
5.
Breinbjerg A, Jorgensen C, Walters G, Grove J, Als T, Kamperis K, et al.
J Urol
. 2024 Aug;
212(6):851-861.
PMID: 39093873
Purpose: Childhood incontinence is stigmatized and underprioritized, and a basic understanding of its pathogenesis is missing. Our goal was to identify risk-conferring genetic variants in daytime urinary incontinence (DUI). Materials...
6.
Bergstedt J, Pasman J, Ma Z, Harder A, Yao S, Parker N, et al.
Nat Cardiovasc Res
. 2024 Jun;
3(6):754-769.
PMID: 38898929
Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with...
7.
Bergstedt J, Pasman J, Ma Z, Harder A, Yao S, Parker N, et al.
medRxiv
. 2023 Sep;
PMID: 37693619
Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Using genomic data, this study elucidates biological mechanisms, key risk factors, and causal...
8.
Als T, Kurki M, Grove J, Voloudakis G, Therrien K, Tasanko E, et al.
Nat Med
. 2023 Jul;
29(7):1832-1844.
PMID: 37464041
Depression is a common psychiatric disorder and a leading cause of disability worldwide. Here we conducted a genome-wide association study meta-analysis of six datasets, including >1.3 million individuals (371,184 with...
9.
Demontis D, Walters G, Athanasiadis G, Walters R, Therrien K, Nielsen T, et al.
Nat Genet
. 2023 Mar;
55(4):730.
PMID: 36859734
No abstract available.
10.
I Kongsstovu S, Mikalsen S, I Homrum E, Jacobsen J, Als T, Gislason H, et al.
Fish Res
. 2023 Feb;
249:106231.
PMID: 36798657
The Atlantic herring L has a vast geographical distribution and a complex population structure with a few very large migratory units and many small local populations. Each population has its...