Thomas Calzascia
Overview
Explore the profile of Thomas Calzascia including associated specialties, affiliations and a list of published articles.
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34
Citations
1348
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Recent Articles
1.
Junt T, Calzascia T, Traggiai E, da Costa A, Gergely P, Schett G, et al.
Nat Rev Immunol
. 2025 Mar;
PMID: 40044810
Personalized cell therapies for autoimmune diseases - such as autologous haematopoietic stem cell transplantation and chimeric antigen receptor-expressing T cells - have the potential to achieve sustained remission in patients...
2.
Hoyler T, Bannert B, Andre C, Beck D, Boulay T, Buffet D, et al.
JCI Insight
. 2022 Jul;
7(13).
PMID: 35801586
IL-1 receptor-activated kinase 1 (IRAK1) is involved in signal transduction downstream of many TLRs and the IL-1R. Its potential as a drug target for chronic inflammatory diseases is underappreciated. To...
3.
Israel L, Gluck A, Berger M, Coral M, Ceci M, Unterreiner A, et al.
Oncogenesis
. 2021 Apr;
10(4):32.
PMID: 33824280
CARD-CC complexes involving BCL10 and MALT1 are major cellular signaling hubs. They govern NF-κB activation through their scaffolding properties as well as MALT1 paracaspase function, which cleaves substrates involved in...
4.
Quancard J, Simic O, Soldermann C, Aichholz R, Blatter M, Renatus M, et al.
J Med Chem
. 2020 Nov;
63(23):14594-14608.
PMID: 33216547
The paracaspase MALT1 has gained increasing interest as a target for the treatment of subsets of lymphomas as well as autoimmune diseases, and there is a need for suitable compounds...
5.
Lu H, Molony R, Chen D, Jang S, Wolf B, Ewert S, et al.
Mol Cancer Ther
. 2020 Aug;
19(10):2089-2104.
PMID: 32847974
The sole inhibitory Fcγ receptor CD32b (FcγRIIb) is expressed throughout B and plasma cell development and on their malignant counterparts. CD32b expression on malignant B cells is known to provide...
6.
Martin K, Junker U, Tritto E, Sutter E, Rubic-Schneider T, Morgan H, et al.
Front Immunol
. 2020 May;
11:745.
PMID: 32425939
Genetic disruption or short-term pharmacological inhibition of MALT1 protease is effective in several preclinical models of autoimmunity and B cell malignancies. Despite these protective effects, the severe reduction in regulatory...
7.
Martin K, Touil R, Cvijetic G, Israel L, Kolb Y, Sarret S, et al.
Arthritis Rheumatol
. 2020 Jan;
72(6):919-930.
PMID: 31943941
Objective: Fcγ receptors (FcγR) play important roles in both protective and pathogenic immune responses. The assembly of the CBM signalosome encompassing caspase recruitment domain-containing protein 9, B cell CLL/lymphoma 10,...
8.
Martin K, Touil R, Kolb Y, Cvijetic G, Murakami K, Israel L, et al.
J Immunol
. 2019 Oct;
203(11):2791-2806.
PMID: 31659015
The paracaspase Malt1 is a key regulator of canonical NF-κB activation downstream of multiple receptors in both immune and nonimmune cells. Genetic disruption of Malt1 protease function in mice and...
9.
Unterreiner A, Touil R, Anastasi D, Dubois N, Niwa S, Calzascia T, et al.
J Vis Exp
. 2019 Jan;
(143).
PMID: 30663686
Besides its function in lymphoid cells, which has been addressed by numerous studies, the paracaspase MALT1 also plays an important role in innate cells downstream of pattern recognition receptors. Best...
10.
Bardet M, Unterreiner A, Malinverni C, Lafossas F, Vedrine C, Boesch D, et al.
Immunol Cell Biol
. 2018 Jan;
96(1):81-99.
PMID: 29359407
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is essential for immune responses triggered by antigen receptors but the contribution of its paracaspase activity is not fully understood. Here, we...