Thomas C Luke
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Explore the profile of Thomas C Luke including associated specialties, affiliations and a list of published articles.
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19
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1126
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Recent Articles
1.
Reed D, McElroy A, Barbeau D, McMillen C, Tilston-Lunel N, Nambulli S, et al.
PLoS One
. 2024 Jun;
19(6):e0290909.
PMID: 38900732
Since SARS-CoV-2 emerged in late 2019, it spread from China to the rest of the world. An initial concern was the potential for vaccine- or antibody-dependent enhancement (ADE) of disease...
2.
Tang J, Grubbs G, Lee Y, Wu H, Luke T, Egland K, et al.
J Infect Dis
. 2022 Feb;
226(4):655-663.
PMID: 35106573
Passive antibody immunotherapeutics directed against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are promising countermeasures for protection and treatment of coronavirus disease 2019 (COVID-19). SARS-CoV-2 variants of concern (VOCs) and...
3.
Liu Z, Wu H, Egland K, Gilliland T, Dunn M, Luke T, et al.
Hum Vaccin Immunother
. 2021 Jul;
18(2):1940652.
PMID: 34228597
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with amino-acid substitutions and deletions in spike protein (S) can reduce the effectiveness of monoclonal antibodies (mAbs) and may compromise immunity induced...
4.
Duplessis C, Luke T, Watters C, Alcorta Y, Biswas B
Mil Med
. 2021 Jun;
188(3-4):e463-e467.
PMID: 34179992
Introduction: Staphylococcus aureus (SA) is a major human bacterial pathogen increasingly refractory to antibiotics. Given the dearth of novel antibiotics in the developmental pipeline, we require concerted efforts at optimizing...
5.
Morrison B, Martin N, Rehman T, Ewing D, Dewar R, Metcalf J, et al.
BMC Health Serv Res
. 2018 Aug;
18(1):651.
PMID: 30134892
Background: The hemagglutination-inhibition (HAI) assay is a critical component for measurement of immunogenicity in influenza vaccine development. It is unknown if the results can be influenced by sample type and...
6.
Danko J, Kochel T, Teneza-Mora N, Luke T, Raviprakash K, Sun P, et al.
Am J Trop Med Hyg
. 2018 Jan;
98(3):849-856.
PMID: 29363446
We conducted an open label, dose escalation Phase 1 clinical trial of a tetravalent dengue DNA vaccine (TVDV) formulated in Vaxfectin to assess safety and immunogenicity. A total of 40...
7.
Morrison B, Roman J, Luke T, Nagabhushana N, Raviprakash K, Williams M, et al.
J Virol Methods
. 2017 Jun;
248:7-18.
PMID: 28624584
This study describes an antibody-dependent NK cell degranulation assay, as a biomarker to assess antibody-dependent cellular cytotoxicity (ADCC) response in influenza plasma and for antibody therapies against influenza infection. The...
8.
Hickey B, Lumsden J, Reyes S, Sedegah M, Hollingdale M, Freilich D, et al.
Malar J
. 2016 Jul;
15(1):377.
PMID: 27448805
Background: In this phase 1 clinical trial, healthy adult, malaria-naïve subjects were immunized with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) by mosquito bite and then underwent controlled human malaria infection (CHMI)....
9.
Dye J, Wu H, Hooper J, Khurana S, Kuehne A, Coyle E, et al.
Sci Rep
. 2016 Apr;
6:24897.
PMID: 27109916
Polyclonal antibodies, derived from humans or hyperimmunized animals, have been used prophylactically or therapeutically as countermeasures for a variety of infectious diseases. SAB Biotherapeutics has successfully developed a transchromosomic (Tc)...
10.
Arabi Y, Balkhy H, Hajeer A, Bouchama A, Hayden F, Al-Omari A, et al.
Springerplus
. 2015 Dec;
4:709.
PMID: 26618098
As of September 30, 2015, a total of 1589 laboratory-confirmed cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization (WHO)....