Thomas Bonacci
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Explore the profile of Thomas Bonacci including associated specialties, affiliations and a list of published articles.
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23
Citations
413
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Recent Articles
1.
Bolhuis D, Fleifel D, Bonacci T, Wang X, Mouery B, Cook J, et al.
bioRxiv
. 2024 Sep;
PMID: 39282338
The CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability. However, factors that prevent premature...
2.
Mouery R, Lukasik K, Hsu C, Bonacci T, Bolhuis D, Wang X, et al.
Cell Rep
. 2024 Jul;
43(8):114510.
PMID: 39018246
Ubiquitination is an essential regulator of cell division. The kinase Polo-like kinase 1 (PLK1) promotes protein degradation at G2/M phase through the E3 ubiquitin ligase Skp1-Cul1-F box (SCF). However, the...
3.
Bonacci T, Bolhuis D, Brown N, Emanuele M
bioRxiv
. 2024 Jun;
PMID: 38853827
The ubiquitin-like protein ISG15 (interferon-stimulated gene 15) regulates the host response to bacterial and viral infections through its conjugation to proteins (ISGylation) following interferon production. ISGylation is antagonized by the...
4.
Choudhury R, Bonacci T, Arceci A, Lahiri D, Mills C, Kernan J, et al.
Cell Rep
. 2024 Mar;
43(3):113974.
PMID: 38457340
No abstract available.
5.
Mouery R, Hsu C, Bonacci T, Bolhuis D, Wang X, Mills C, et al.
bioRxiv
. 2023 Oct;
PMID: 37873169
Targeted protein degradation by the ubiquitin-proteasome system is an essential mechanism regulating cellular division. The kinase PLK1 coordinates protein degradation at the G2/M phase of the cell cycle by promoting...
6.
Bodrug T, Welsh K, Bolhuis D, Paulakonis E, Martinez-Chacin R, Liu B, et al.
Nat Struct Mol Biol
. 2023 Sep;
30(11):1663-1674.
PMID: 37735619
Substrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is highly dynamic, and obtaining mechanistic insight has thus far required artificially trapped...
7.
Welsh K, Bolhuis D, Nederstigt A, Boyer J, Temple B, Bonacci T, et al.
EMBO J
. 2021 Dec;
41(3):e108823.
PMID: 34942047
Polyubiquitination by E2 and E3 enzymes is crucial to cell cycle control, epigenetic regulation, and development. The hallmark of the E2 family is the ubiquitin (Ub)-conjugating (UBC) domain that forms...
8.
Franks J, Martinez-Chacin R, Wang X, Tiedemann R, Bonacci T, Choudhury R, et al.
PLoS Biol
. 2020 Dec;
18(12):e3000975.
PMID: 33306668
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of cell cycle progression. Despite its vital role, it has remained challenging to globally map APC/C substrates. By...
9.
Martinez-Chacin R, Bodrug T, Bolhuis D, Kedziora K, Bonacci T, Ordureau A, et al.
Nat Struct Mol Biol
. 2020 May;
27(6):550-560.
PMID: 32393902
The interplay between E2 and E3 enzymes regulates the polyubiquitination of substrates in eukaryotes. Among the several RING-domain E3 ligases in humans, many utilize two distinct E2s for polyubiquitination. For...
10.
Bonacci T, Emanuele M
Semin Cancer Biol
. 2020 Mar;
67(Pt 2):145-158.
PMID: 32201366
Since its discovery forty years ago, protein ubiquitination has been an ever-expanding field. Virtually all biological processes are controlled by the post-translational conjugation of ubiquitin onto target proteins. In addition,...