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Thomas Anantharaman

Explore the profile of Thomas Anantharaman including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 956
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Recent Articles
1.
Chaisson M, Sanders A, Zhao X, Malhotra A, Porubsky D, Rausch T, et al.
Nat Commun . 2019 Apr; 10(1):1784. PMID: 30992455
The incomplete identification of structural variants (SVs) from whole-genome sequencing data limits studies of human genetic diversity and disease association. Here, we apply a suite of long-read, short-read, strand-specific sequencing...
2.
Mak A, Lai Y, Lam E, Kwok T, Leung A, Poon A, et al.
Genetics . 2015 Oct; 202(1):351-62. PMID: 26510793
Comprehensive whole-genome structural variation detection is challenging with current approaches. With diploid cells as DNA source and the presence of numerous repetitive elements, short-read DNA sequencing cannot be used to...
3.
Shelton J, Coleman M, Herndon N, Lu N, Lam E, Anantharaman T, et al.
BMC Genomics . 2015 Sep; 16:734. PMID: 26416786
Background: Genome assembly remains an unsolved problem. Assembly projects face a range of hurdles that confound assembly. Thus a variety of tools and approaches are needed to improve draft genomes....
4.
Pendleton M, Sebra R, Pang A, Ummat A, Franzen O, Rausch T, et al.
Nat Methods . 2015 Jun; 12(8):780-6. PMID: 26121404
We present the first comprehensive analysis of a diploid human genome that combines single-molecule sequencing with single-molecule genome maps. Our hybrid assembly markedly improves upon the contiguity observed from traditional...
5.
Cao H, Hastie A, Cao D, Lam E, Sun Y, Huang H, et al.
Gigascience . 2015 Feb; 3(1):34. PMID: 25671094
Background: Structural variants (SVs) are less common than single nucleotide polymorphisms and indels in the population, but collectively account for a significant fraction of genetic polymorphism and diseases. Base pair...
6.
Wu H, Kim K, Mehta K, Paxia S, Sundstrom A, Anantharaman T, et al.
Stem Cells . 2008 Mar; 26(6):1484-9. PMID: 18369100
Differences between individual DNA sequences provide the basis for human genetic variability. Forms of genetic variation include single-nucleotide polymorphisms, insertions/duplications, deletions, and inversions/translocations. The genome of human embryonic stem cells...
7.
Mishra B, Daruwala R, Zhou Y, Ugel N, Policriti A, Antoniotti M, et al.
OMICS . 2003 Oct; 7(3):253-68. PMID: 14583115
We collaborate in a research program aimed at creating a rigorous framework, experimental infrastructure, and computational environment for understanding, experimenting with, manipulating, and modifying a diverse set of fundamental biological...