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Thomas A Rasmussen

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Articles 62
Citations 1979
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Recent Articles
1.
Pascoe R, Kim Y, Rhodes A, Ong J, Tumpach C, Gubser C, et al.
J Virol . 2025 Feb; :e0167624. PMID: 39902962
HIV persists in people living with HIV (PLHIV) on antiretroviral therapy (ART) in long-lived and proliferating latently infected CD4+ T cells that selectively express pro-survival proteins, including the zinc finger...
2.
Gubser C, Pascoe R, Trautmann L, Rasmussen T, Lewin S
STAR Protoc . 2024 Aug; 5(3):103231. PMID: 39116199
Here, we present a protocol to evaluate the killing capacity and functional profile of human HIV-specific CD8 T cells. We describe steps for culturing peripheral blood mononuclear cells (PBMCs) from...
3.
Gubser C, Pascoe R, Chang J, Chiu C, Solomon A, Cao R, et al.
iScience . 2023 Nov; 26(11):108165. PMID: 38026168
Glucocorticoid-induced tumor necrosis factor related protein (GITR) is a co-stimulatory immune checkpoint molecule constitutively expressed on regulatory T cells (T) and on activated T conventional cells (T). In blood collected...
4.
Gunst J, Goonetilleke N, Rasmussen T, Sogaard O
J Virus Erad . 2023 Sep; 9(3):100347. PMID: 37767312
Immunomodulating agents are substances that modify the host immune responses in diseases such as infections, autoimmune conditions and cancers. Immunomodulators can be divided into two main groups: 1) immunostimulators that...
5.
Pitman M, Meagher N, Price D, Rhodes A, Chang J, Scher B, et al.
J Virus Erad . 2023 Sep; 9(3):100345. PMID: 37753336
Introduction: Antiretroviral therapy for people living with HIV-1 must be taken lifelong due to the persistence of latent virus in long-lived and proliferating CD4 T cells. Vitamin D is a...
6.
Gunst J, Hojen J, Pahus M, Rosas-Umbert M, Stiksrud B, McMahon J, et al.
Nat Med . 2023 Sep; 29(10):2547-2558. PMID: 37696935
Inducing antiretroviral therapy (ART)-free virological control is a critical step toward a human immunodeficiency virus type 1 (HIV-1) cure. In this phase 2a, placebo-controlled, double-blinded trial, 43 people (85% males)...
7.
Chiu C, Schou M, McMahon J, Deeks S, Fromentin R, Chomont N, et al.
Front Immunol . 2023 Apr; 14:1123342. PMID: 37056754
Introduction: In people with HIV (PWH) both off and on antiretroviral therapy (ART), the expression of immune checkpoint (IC) proteins is elevated on the surface of total and HIV-specific T-cells,...
8.
Fisher K, Schlub T, Boyer Z, Rasmussen T, Rhodes A, Hoh R, et al.
Front Immunol . 2023 Feb; 14:1064346. PMID: 36776833
Introduction: HIV-1 persists in resting CD4 T-cells despite antiretroviral therapy (ART). Determining the cell surface markers that enrich for genetically-intact HIV-1 genomes is vital in developing targeted curative strategies. Previous...
9.
Rasmussen L, Lebech A, Ovrehus A, Poulsen B, Christensen H, Nielsen H, et al.
Br J Clin Pharmacol . 2022 Dec; 89(6):1820-1833. PMID: 36519217
Aims: To evaluate the experience with use of sotrovimab following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in high-risk groups. Methods: In a nationwide, population-based cohort study, we identified all...
10.
Rasmussen T, Zerbato J, Rhodes A, Tumpach C, Dantanarayana A, McMahon J, et al.
Cell Rep Med . 2022 Oct; 3(10):100766. PMID: 36198308
Programmed cell death 1 (PD1) and cytotoxic T lymphocyte-associated protein 4 (CTLA4) suppress CD4 T cell activation and may promote latent HIV infection. By performing leukapheresis (n = 21) and...