Thomas A Mackenzie
Overview
Explore the profile of Thomas A Mackenzie including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
46
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Recent Articles
1.
Castillo F, Ramirez D, Ramos M, Martinez-Arribas B, Domingo-Contreras E, Mackenzie T, et al.
Front Pharmacol
. 2024 Jul;
15:1390705.
PMID: 39050758
The SARS coronavirus 2 (SARS-CoV-2) epidemic remains globally active. The emergence of new variants of interest and variants of concern (VoCs), which are potentially more vaccine-resistant and less sensitive to...
2.
Fernandez-Pastor I, Gonzalez-Menendez V, Gonzalez I, Serrano R, Mackenzie T, Benitez G, et al.
J Agric Food Chem
. 2024 Jun;
72(27):15256-15264.
PMID: 38935555
A study targeting novel antifungal metabolites identified potent antifungal activity against key plant pathogens in acetone extracts of sp. strain CA-296093. Feature-based molecular networking revealed the presence in this extract...
3.
Domingo-Contreras E, Tormo J, Gonzalez-Menendez V, Mackenzie T, Martin-Serrano J, Magiera-Mularz K, et al.
Int J Biol Macromol
. 2024 Feb;
264(Pt 1):130458.
PMID: 38423421
The PD-1/PD-L1 protein-protein interaction (PPI) controls an adaptive immune resistance mechanism exerted by tumor cells to evade immune responses. The large-molecule nature of current commercial monoclonal antibodies against this PPI...
4.
Vitorino I, Pinto E, Martin J, Mackenzie T, Ramos M, Sanchez P, et al.
Antonie Van Leeuwenhoek
. 2024 Jan;
117(1):26.
PMID: 38261060
An appealing strategy for finding novel bioactive molecules in Nature consists in exploring underrepresented and -studied microorganisms. Here, we investigated the antimicrobial and tumoral anti-proliferative bioactivities of twenty-three marine and...
5.
Mackenzie T, Reyes F, Martinez M, Gonzalez-Menendez V, Sanchez I, Genilloud O, et al.
Molecules
. 2024 Jan;
29(2).
PMID: 38257340
Cancer is one of the leading causes of death worldwide, with breast cancer being the second cause of cancer-related mortality among women. Natural Products (NPs) are one of the main...
6.
Virues-Segovia J, Millan C, Pinedo C, Gonzalez-Rodriguez V, Papaspyrou S, Zorrilla D, et al.
Mar Drugs
. 2023 Dec;
21(12).
PMID: 38132955
The fungal strain BC17 was isolated from sediments collected in the intertidal zone of the inner Bay of Cadiz and characterized as . On the basis of the one strain-many...
7.
Martinez-Arribas B, Annang F, Diaz-Gonzalez R, Perez-Moreno G, Martin J, Mackenzie T, et al.
Microbiol Spectr
. 2023 Nov;
12(1):e0167923.
PMID: 38009959
The COVID-19 pandemic has revealed the lack of effective treatments against betacoronaviruses and the urgent need for new broad-spectrum antivirals. Natural products are a valuable source of bioactive compounds with...
8.
Mackenzie T, Tormo J, Cautain B, Martinez G, Sanchez I, Genilloud O, et al.
SLAS Technol
. 2023 Oct;
29(3):100111.
PMID: 37898289
Natural Products (NPs) are one of the main sources for drug discovery. Many clinical drugs are NPs or NP-inspired compounds, and recently discovered New Chemical Entities (NCEs) of NPs are...
9.
Fernandez-Pastor I, Gonzalez-Menendez V, Martinez Andrade K, Serrano R, Mackenzie T, Benitez G, et al.
J Fungi (Basel)
. 2023 Sep;
9(9).
PMID: 37754995
In a survey to evaluate the potential of lichens associated with gypsum areas as sources of new antifungal metabolites, six species of lichens were collected in the gypsum outcrops of...
10.
Kokkini M, Oves-Costales D, Sanchez P, Melguizo A, Mackenzie T, Perez-Bonilla M, et al.
Mar Drugs
. 2023 Aug;
21(8).
PMID: 37623724
Antimicrobial resistance can be considered a hidden global pandemic and research must be reinforced for the discovery of new antibiotics. The spirotetronate class of polyketides, with more than 100 bioactive...