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Thomas A Angelovich

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Citations 774
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Recent Articles
1.
Jamal Eddine J, Angelovich T, Zhou J, Byrnes S, Tumpach C, Saraya N, et al.
PLoS Pathog . 2024 Aug; 20(8):e1012446. PMID: 39116185
HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated neurocognitive disorders. Whether HIV transcription persists in the brain despite viral suppression with antiretroviral therapy...
2.
Angelovich T, Cochrane C, Zhou J, Tumpach C, Byrnes S, Jamal Eddine J, et al.
Ann Neurol . 2023 Jul; 94(4):798-802. PMID: 37493435
Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV...
3.
Tumpach C, Cochrane C, Kim Y, Ong J, Rhodes A, Angelovich T, et al.
J Virus Erad . 2023 Jul; 9(2):100335. PMID: 37440871
Quantification of intact proviruses is a critical measurement in HIV cure studies both and . The widely adopted 'intact proviral DNA assay' (IPDA), designed to discriminate and quantify genetically intact...
4.
Byrnes S, Busman-Sahay K, Angelovich T, Younger S, Taylor-Brill S, Nekorchuk M, et al.
PLoS Pathog . 2023 Mar; 19(3):e1011290. PMID: 36989320
HIV-associated neurocognitive disorders (HAND) affect ~40% of virally suppressed people with HIV (PWH), however, the precise viral dependent and independent changes to the brain are unclear. Here we characterized the...
5.
Gartner M, Tumpach C, Dantanarayana A, Stern J, Zerbato J, Chang J, et al.
AIDS . 2022 Dec; 37(2):247-257. PMID: 36541637
Objectives: Despite suppressive antiretroviral therapy (ART), HIV can persist in a diverse range of CD4+ T-cell subsets. Through longitudinal env sampling from people with HIV (PWH) on ART, we characterized...
6.
Byrnes S, Angelovich T, Busman-Sahay K, Cochrane C, Roche M, Estes J, et al.
Viruses . 2022 Sep; 14(9). PMID: 36146803
Human Immunodeficiency virus (HIV)-associated neurocognitive disorders are a major burden for people living with HIV whose viremia is stably suppressed with antiretroviral therapy. The pathogenesis of disease is likely multifaceted,...
7.
Cochrane C, Angelovich T, Byrnes S, Waring E, Guanizo A, Trollope G, et al.
Ann Neurol . 2022 Jul; 92(4):532-544. PMID: 35867351
Objective: Human immunodeficiency virus (HIV) persistence in blood and tissue reservoirs, including the brain, is a major barrier to HIV cure and possible cause of comorbid disease. However, the size...
8.
Buckley S, Byrnes S, Cochrane C, Roche M, Estes J, Selemidis S, et al.
Brain Behav Immun Health . 2021 Sep; 13:100235. PMID: 34589750
HIV-associated neurocognitive disorders (HAND) are a leading cause of morbidity in up to 50% of individuals living with HIV, despite effective treatment with antiretroviral therapy (ART). Current evidence suggests that...
9.
Hearps A, Angelovich T, Trevillyan J, Wong M, Calmy A, Hoy J, et al.
J Infect Dis . 2021 Aug; 224(4):667-672. PMID: 34398237
Background: Statins may help prevent cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH) with chronic inflammation owing to their pleotropic lipid-lowering and anti-inflammatory properties. Methods: The impact of...
10.
Gartner M, Gorry P, Tumpach C, Zhou J, Dantanarayana A, Chang J, et al.
Retrovirology . 2020 Aug; 17(1):24. PMID: 32762760
Background: HIV-1 infects a wide range of CD4 T cells with different phenotypic properties and differing expression levels of entry coreceptors. We sought to determine the viral tropism of subtype...