Thierry Sulpice
Overview
Explore the profile of Thierry Sulpice including associated specialties, affiliations and a list of published articles.
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41
Citations
3767
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Recent Articles
11.
Briand F, Maupoint J, Brousseau E, Breyner N, Bouchet M, Costard C, et al.
Metabolism
. 2021 Jan;
117:154707.
PMID: 33444606
Background: Cardiovascular disease is the leading cause of deaths in nonalcoholic steatohepatitis (NASH) patients. Mouse models, while widely used for drug development, do not fully replicate human NASH nor integrate...
12.
Kasbi Chadli F, Treguier M, Briand F, Sulpice T, Ouguerram K
J Pharmacol Exp Ther
. 2020 Sep;
375(2):349-356.
PMID: 32873624
The aim of this work was to evaluate reverse cholesterol transport (RCT) in hamster, animal model expressing CETP under a high cholesterol diet (HF) supplemented with Ezetimibe using primary labelled...
13.
Morigny P, Houssier M, Mairal A, Ghilain C, Mouisel E, Benhamed F, et al.
Nat Metab
. 2020 Jul;
1(1):133-146.
PMID: 32694809
Impaired adipose tissue insulin signalling is a critical feature of insulin resistance. Here we identify a pathway linking the lipolytic enzyme hormone-sensitive lipase (HSL) to insulin action via the glucose-responsive...
14.
Briand F, Brousseau E, Maupoint J, Dubroca C, Costard C, Breyner N, et al.
Eur J Pharmacol
. 2020 Jul;
882:173316.
PMID: 32621913
Lorcaserin (LORCA) and liraglutide (LIRA) were evaluated in a novel diet-induced obese (DIO) rat model fed a free choice (FC) diet, that presents rats with the options between control chow...
15.
Briand F, Heymes C, Bonada L, Angles T, Charpentier J, Branchereau M, et al.
Clin Transl Sci
. 2020 Jan;
13(3):529-538.
PMID: 31981449
The long duration of animal models represents a clear limitation to quickly evaluate the efficacy of drugs targeting nonalcoholic steatohepatitis (NASH). We, therefore, developed a rapid mouse model of liver...
16.
Duparc T, Briand F, Trenteseaux C, Merian J, Combes G, Najib S, et al.
Am J Physiol Gastrointest Liver Physiol
. 2019 Aug;
317(4):G508-G517.
PMID: 31460789
Nonalcoholic steatohepatitis (NASH) is an emerging health problem worldwide. However, efficacious pharmacological treatment for NASH is lacking. A major issue for preclinical evaluation of potential therapeutics for NASH is the...
17.
Norgaard S, Briand F, Sand F, Galsgaard E, Sondergaard H, Sorensen D, et al.
Eur J Pharmacol
. 2019 Jul;
860:172537.
PMID: 31310751
The widely used db/db mouse as a model of diabetic nephropathy (DN) only mimics the early changes in human DN with a slow disease progression. Since high protein diet (HPD)...
18.
Briand F, Brousseau E, Quinsat M, Burcelin R, Sulpice T
Eur J Pharmacol
. 2017 Nov;
818:449-456.
PMID: 29155143
The use of rat and mouse models limits the translation to humans for developing novel drugs targeting nonalcoholic steatohepatitis (NASH). Obeticholic acid (OCA) illustrates this limitation since its dyslipidemic effect...
19.
Dumas L, Briand F, Clerc R, Brousseau E, Montemagno C, Ahmadi M, et al.
J Nucl Med
. 2017 Mar;
58(7):1088-1093.
PMID: 28280218
The addition of ezetimibe, an intestinal cholesterol absorption inhibitor, to statin therapy has recently shown clinical benefits in the Improved Reduction of Outcomes: Vytorin Efficacy International Trial by reducing low-density-lipoprotein...
20.
Li J, Casteels T, Frogne T, Ingvorsen C, Honore C, Courtney M, et al.
Cell
. 2016 Dec;
168(1-2):86-100.e15.
PMID: 27916275
Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating new insulin-producing cells from other cell types is a major aim of regenerative medicine. One promising...