Theresa Thor
Overview
Explore the profile of Theresa Thor including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
626
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Gottlieb A, Althoff K, Grunewald L, Thor T, Odersky A, Schulte M, et al.
Oncotarget
. 2017 Apr;
8(17):27882-27891.
PMID: 28427187
Current therapy of medulloblastoma, the most common malignant brain tumor of childhood, achieves 40-70% survival. Secondary chemotherapy resistance contributes to treatment failure, where TP53 pathway dysfunction plays a key role....
2.
Pajtler K, Sadowski N, Ackermann S, Althoff K, Schonbeck K, Batzke K, et al.
Oncotarget
. 2016 Dec;
8(4):6730-6741.
PMID: 28036269
Polo-like kinase 1 (PLK1) is a serine/threonine kinase that promotes G2/M-phase transition, is expressed in elevated levels in high-risk neuroblastomas and correlates with unfavorable patient outcome. Recently, we and others...
3.
Thor T, Kunkele A, Pajtler K, Wefers A, Stephan H, Mestdagh P, et al.
Int J Cancer
. 2014 Oct;
136(10):2293-303.
PMID: 25348795
Previous studies have evaluated the role of miRNAs in cancer initiation and progression. MiR-34a was found to be downregulated in several tumors, including medulloblastomas. Here we employed targeted transgenesis to...
4.
Pajtler K, Weingarten C, Thor T, Kunkele A, Heukamp L, Buttner R, et al.
Acta Neuropathol Commun
. 2013 Nov;
1:19.
PMID: 24252778
Background: Medulloblastoma is a leading cause of childhood cancer-related deaths. Current aggressive treatments frequently lead to cognitive and neurological disabilities in survivors. Novel targeted therapies are required to improve outcome...
5.
Henssen A, Thor T, Odersky A, Heukamp L, El-Hindy N, Beckers A, et al.
Oncotarget
. 2013 Nov;
4(11):2080-95.
PMID: 24231268
Medulloblastoma is the most common malignant brain tumor of childhood, and represents a significant clinical challenge in pediatric oncology, since overall survival currently remains under 70%. Patients with tumors overexpressing...
6.
Molenaar J, Domingo-Fernandez R, Ebus M, Lindner S, Koster J, Drabek K, et al.
Nat Genet
. 2012 Oct;
44(11):1199-206.
PMID: 23042116
LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7 family. A role for LIN28B in cancer has been proposed but has not been established in vivo. Here, we...
7.
Heukamp L, Thor T, Schramm A, De Preter K, Kumps C, De Wilde B, et al.
Sci Transl Med
. 2012 Jul;
4(141):141ra91.
PMID: 22764207
Activating anaplastic lymphoma kinase (ALK) mutations were recently detected in most familial and 10% of sporadic neuroblastomas. However, the role of mutated ALK in tumorigenesis remains elusive. We demonstrate that...
8.
Kunkele A, De Preter K, Heukamp L, Thor T, Pajtler K, Hartmann W, et al.
Neuro Oncol
. 2012 May;
14(7):859-69.
PMID: 22591662
Medulloblastomas account for 20% of pediatric brain tumors. With an overall survival of 40%-70%, their treatment is still a challenge. The majority of medulloblastomas lack p53 mutations, but even in...
9.
Schulte J, Schowe B, Mestdagh P, Kaderali L, Kalaghatgi P, Schlierf S, et al.
Int J Cancer
. 2010 May;
127(10):2374-85.
PMID: 20473924
For neuroblastoma, the most common extracranial tumour of childhood, identification of new biomarkers and potential therapeutic targets is mandatory to improve risk stratification and survival rates. MicroRNAs are deregulated in...
10.
Schulte J, Marschall T, Martin M, Rosenstiel P, Mestdagh P, Schlierf S, et al.
Nucleic Acids Res
. 2010 May;
38(17):5919-28.
PMID: 20466808
Small non-coding RNAs, in particular microRNAs(miRNAs), regulate fine-tuning of gene expression and can act as oncogenes or tumor suppressor genes. Differential miRNA expression has been reported to be of functional...