Thangavel Samikkannu
Overview
Explore the profile of Thangavel Samikkannu including associated specialties, affiliations and a list of published articles.
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48
Citations
864
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Recent Articles
1.
Chennakesavan K, Haorah J, Samikkannu T
Mol Ther Nucleic Acids
. 2025 Mar;
36(1):102473.
PMID: 40083650
P-element-induced wimpy (PIWI)-interacting RNAs (piRNAs) and PIWI proteins have long been studied in insects and germline cells for their roles in regulating transposable elements (TEs). However, emerging evidence suggests that...
2.
Haorah J, Malaroviyam S, Iyappan H, Samikkannu T
Front Med (Lausanne)
. 2025 Jan;
11:1505440.
PMID: 39839621
Human immunodeficiency virus (HIV) infection is the cause of acquired immunodeficiency syndrome (AIDS). Combination antiretroviral therapy (cART) has successfully controlled AIDS, but HIV-associated neurocognitive disorders (HANDs) remain prevalent among people...
3.
Ramasamy T, Doke M, McLaughlin J, Samikkannu T
Brain Behav Immun Health
. 2023 Jul;
31:100659.
PMID: 37455861
Background: Previous studies have indicated a close link between the inflammatory response, exacerbated by circadian disruption and psychostimulants such as cocaine and methamphetamine (METH). Indicators of this inflammation include cortisol...
4.
Doke M, McLaughlin J, Baniasadi H, Samikkannu T
Metabolites
. 2022 Sep;
12(9).
PMID: 36144274
Disturbances in the circadian rhythm alter the normal sleep-wake cycle, which increases vulnerability to drug abuse. Drug abuse can disrupt several homeostatic processes regulated by the circadian rhythm and influence...
5.
Sundar V, McLaughlin J, Samikkannu T
Mol Brain
. 2022 Aug;
15(1):69.
PMID: 35941658
HIV is a major global public threat burdening society, yet the exact mechanism of HIV pathogenesis needs to be elucidated. In the era of epigenetic therapy, N-terminal acetylation (Nt-acetylation) changes...
6.
Doke M, McLaughlin J, Cai J, Pendyala G, Kashanchi F, Khan M, et al.
Mol Ther Nucleic Acids
. 2022 Jul;
29:243-258.
PMID: 35892093
Clinical research has proven that HIV-positive (HIV) individuals with cocaine abuse show behavioral and neurocognitive disorders. Noncoding RNAs (ncRNAs), such as long ncRNAs (lncRNAs) and microRNAs (miRNAs), are known to...
7.
Sundar V, Ramasamy T, Doke M, Samikkannu T
Redox Rep
. 2022 Mar;
27(1):53-59.
PMID: 35227168
Psychostimulant use induces oxidative stress and alters redox imbalance, influencing epigenetic signatures in the central nervous system (CNS). Among the various epigenetic changes, DNA methylation is directly linked to oxidative...
8.
Doke M, Kashanchi F, Khan M, Samikkannu T
Epigenomics
. 2022 Feb;
14(5):261-278.
PMID: 35170353
To understand the effect of HIV infection and cocaine exposure on piRNA expression in human primary astrocytes. We used small RNA sequencing analysis to investigate the impacts of HIV-1 Tat...
9.
Doke M, Ramasamy T, Sundar V, McLaughlin J, Samikkannu T
Brain Sci
. 2021 Nov;
11(11).
PMID: 34827437
The chronic irreversible regression of cognitive ability and memory function in human immunodeficiency virus (HIV)-associated dementia (HAND) is linked with late-stage HIV infection in the brain. The molecular-level signatures of...
10.
Sivalingam K, Doke M, Khan M, Samikkannu T
Sci Rep
. 2021 Oct;
11(1):21335.
PMID: 34716387
Substance abuse affects the central nervous system (CNS) and remains a global health problem. Psychostimulants, such as cocaine and methamphetamine (METH), and opioids affect neuronal function and lead to behavioral...