Tetsushi Yamagata
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Explore the profile of Tetsushi Yamagata including associated specialties, affiliations and a list of published articles.
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10
Citations
398
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Recent Articles
1.
Yamagata T, Ogiwara I, Tatsukawa T, Suzuki T, Otsuka Y, Imaeda N, et al.
Elife
. 2023 May;
12.
PMID: 37219072
Expressions of voltage-gated sodium channels Nav1.1 and Nav1.2, encoded by and genes, respectively, have been reported to be mutually exclusive in most brain regions. In juvenile and adult neocortex, Nav1.1...
2.
Yamagata T, Raveau M, Kobayashi K, Miyamoto H, Tatsukawa T, Ogiwara I, et al.
Neurobiol Dis
. 2020 May;
141:104954.
PMID: 32445790
Dravet syndrome is a severe infantile-onset epileptic encephalopathy which begins with febrile seizures and is caused by heterozygous loss-of-function mutations of the voltage-gated sodium channel gene SCN1A. We designed a...
3.
Miyamoto H, Tatsukawa T, Shimohata A, Yamagata T, Suzuki T, Amano K, et al.
Nat Commun
. 2019 Apr;
10(1):1917.
PMID: 31015467
STXBP1 and SCN2A gene mutations are observed in patients with epilepsies, although the circuit basis remains elusive. Here, we show that mice with haplodeficiency for these genes exhibit absence seizures...
4.
Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, et al.
Commun Biol
. 2018 Sep;
1:96.
PMID: 30175250
Mutations in the gene encoding a voltage-gated sodium channel Nav1.2 are associated with epilepsies, intellectual disability, and autism. gain-of-function mutations cause early-onset severe epilepsies, while loss-of-function mutations cause autism with...
5.
Yamagata T, Ogiwara I, Mazaki E, Yanagawa Y, Yamakawa K
Biochem Biophys Res Commun
. 2017 Aug;
491(4):1070-1076.
PMID: 28784306
Nav1.1 and Nav1.2 are the voltage-gated sodium channel pore-forming alpha I and II subunits, encoded by the genes SCN1A and SCN2A. Although mutations of both genes have similarly been described...
6.
Cornford E, Hyman S, Cornford M, Chytrova G, Rhee J, Suzuki T, et al.
J Drug Target
. 2015 Jul;
24(1):58-67.
PMID: 26133964
Research was undertaken to establish transplacental delivery of active genes to fetal brain by a non-viral vector, antibody-specific targeted therapeutic procedure. PEGylated immunoliposomes (PILs) containing firefly luciferase DNA under the...
7.
Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, et al.
Hum Mol Genet
. 2013 Aug;
22(23):4784-804.
PMID: 23922229
Dravet syndrome is a severe epileptic encephalopathy mainly caused by heterozygous mutations in the SCN1A gene encoding a voltage-gated sodium channel Nav1.1. We previously reported dense localization of Nav1.1 in...
8.
Ogiwara I, Nakayama T, Yamagata T, Ohtani H, Mazaki E, Tsuchiya S, et al.
Epilepsia
. 2012 Nov;
53(12):e200-3.
PMID: 23148524
Dravet syndrome is a severe form of epileptic encephalopathy characterized by early onset epileptic seizures followed by ataxia and cognitive decline. Approximately 80% of patients with Dravet syndrome have been...
9.
Suzuki T, Inoue I, Yamagata T, Morita N, Furuichi T, Yamakawa K
Biochem Biophys Res Commun
. 2008 Jan;
367(1):226-33.
PMID: 18164683
EFHC1 is a gene mutated in patients with idiopathic epilepsies, and encodes the myoclonin1 protein. We here report the distribution of myoclonin1 in mouse. Immunohistochemical analyses revealed that the myoclonin1...
10.
Anzai T, Shiina T, Kimura N, Yanagiya K, Kohara S, Shigenari A, et al.
Proc Natl Acad Sci U S A
. 2003 Jun;
100(13):7708-13.
PMID: 12799463
Despite their high degree of genomic similarity, reminiscent of their relatively recent separation from each other ( approximately 6 million years ago), the molecular basis of traits unique to humans...