Terence H Rabbitts
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Explore the profile of Terence H Rabbitts including associated specialties, affiliations and a list of published articles.
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68
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2089
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Recent Articles
1.
Sikandar S, Gulati G, Antony J, Fetter I, Kuo A, Ho W, et al.
Sci Adv
. 2022 Nov;
8(45):eabm3548.
PMID: 36351009
Metastasis is responsible for most breast cancer-related deaths; however, identifying the cellular determinants of metastasis has remained challenging. Here, we identified a minority population of immature / tumor epithelial cells...
2.
Yamada Y, Zhong Y, Miki S, Taura A, Rabbitts T
Sci Rep
. 2022 May;
12(1):7226.
PMID: 35508511
The transcription factor complex, consisting of LMO2, TAL1 or LYL1, and GATA2, plays an important role in capillary sprouting by regulating VEGFR2, DLL4, and angiopoietin 2 in tip cells. Overexpression...
3.
Hastie K, Li H, Bedinger D, Schendel S, Dennison S, Li K, et al.
Science
. 2021 Sep;
374(6566):472-478.
PMID: 34554826
Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Multiple mutations in SARS-CoV-2 that could impair antibody defenses...
4.
Leach A, Tudor Ilca F, Akbar Z, Ferrari M, Bentley E, Mattiuzzo G, et al.
Antiviral Res
. 2021 Aug;
194:105147.
PMID: 34375715
The SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) was previously engineered into a high affinity tetravalent format (ACE2-Fc-TD) that is a potential decoy protein in SARS-CoV-2 infection.We report that this...
5.
Bery N, Bataille C, Russell A, Hayes A, Raynaud F, Milhas S, et al.
Sci Adv
. 2021 Apr;
7(15).
PMID: 33837087
Intracellular antibodies are tools that can be used directly for target validation by interfering with properties like protein-protein interactions. An alternative use of intracellular antibodies in drug discovery is developing...
6.
Bataille C, Rabbitts T, Claridge T
Bio Protoc
. 2021 Mar;
10(13):e3666.
PMID: 33659336
In drug development programmes, multiple assays are needed for the determination of protein-compound interactions and evaluation of potential use in assays with protein-protein interactions. In this protocol we describe the...
7.
Chabloz A, Schaefer J, Kozieradzki I, Cronin S, Strebinger D, Macaluso F, et al.
Commun Biol
. 2020 Jul;
3(1):342.
PMID: 32620833
Protein-based affinity reagents (like antibodies or alternative binding scaffolds) offer wide-ranging applications for basic research and therapeutic approaches. However, whereas small chemical molecules efficiently reach intracellular targets, the delivery of...
8.
Keller L, Bery N, Tardy C, Ligat L, Favre G, Rabbitts T, et al.
Antibodies (Basel)
. 2019 Sep;
8(1).
PMID: 31544814
RHO (Ras HOmologous) GTPases are molecular switches that activate, in their state bound to Guanosine triphosphate (GTP), key signaling pathways, which involve actin cytoskeleton dynamics. Previously, we selected the nanobody...
9.
Bery N, Legg S, Debreczeni J, Breed J, Embrey K, Stubbs C, et al.
Nat Commun
. 2019 Jun;
10(1):2607.
PMID: 31197133
Inhibiting the RAS oncogenic protein has largely been through targeting the switch regions that interact with signalling effector proteins. Here, we report designed ankyrin repeat proteins (DARPins) macromolecules that specifically...
10.
Chambers J, Brend T, Rabbitts T
Sci Rep
. 2019 Jun;
9(1):8553.
PMID: 31189945
Many tumour causing proteins, such as those expressed after chromosomal translocations or from point mutations, are intracellular and are not enzymes per se amenable to conventional drug targeting. We previously...