Teddy John Wohlbold
Overview
Explore the profile of Teddy John Wohlbold including associated specialties, affiliations and a list of published articles.
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17
Citations
1090
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0
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Recent Articles
1.
Bernstein D, Guptill J, Naficy A, Nachbagauer R, Berlanda-Scorza F, Feser J, et al.
Lancet Infect Dis
. 2019 Oct;
20(1):80-91.
PMID: 31630990
Background: Influenza viruses cause substantial annual morbidity and mortality globally. Current vaccines protect against influenza only when well matched to the circulating strains. However, antigenic drift can cause considerable mismatches...
2.
Arunkumar G, Ioannou A, Wohlbold T, Meade P, Aslam S, Amanat F, et al.
J Virol
. 2019 Jan;
93(6).
PMID: 30626682
Protection from influenza virus infection is canonically associated with antibodies that neutralize the virus by blocking the interaction between the viral hemagglutinin and host cell receptors. However, protection can also...
3.
Chen Y, Wohlbold T, Zheng N, Huang M, Huang Y, Neu K, et al.
Cell
. 2018 Apr;
173(2):417-429.e10.
PMID: 29625056
Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major mediators of protection against influenza virus infection. Here, we report that current influenza vaccines poorly display key NA...
4.
Rajendran M, Sun W, Comella P, Nachbagauer R, Wohlbold T, Amanat F, et al.
PLoS One
. 2018 Apr;
13(4):e0194830.
PMID: 29617394
The standard method to quantify the hemagglutinin content of influenza virus vaccines is the single radial immunodiffusion assay. This assay primarily relies on polyclonal antibodies against the head domain of...
5.
Nachbagauer R, Liu W, Choi A, Wohlbold T, Atlas T, Rajendran M, et al.
NPJ Vaccines
. 2017 Dec;
2:26.
PMID: 29263881
Influenza viruses evade human adaptive immune responses due to continuing antigenic changes. This makes it necessary to re-formulate and re-administer current seasonal influenza vaccines on an annual basis. Our pan-influenza...
6.
Leon P, Wohlbold T, He W, Bailey M, Henry C, Wilson P, et al.
J Vis Exp
. 2017 Sep;
(126).
PMID: 28872136
Influenza viruses exhibit a remarkable ability to adapt and evade the host immune response. One way is through antigenic changes that occur on the surface glycoproteins of the virus. The...
7.
Wohlbold T, Podolsky K, Chromikova V, Kirkpatrick E, Falconieri V, Meade P, et al.
Nat Microbiol
. 2017 Aug;
2(10):1415-1424.
PMID: 28827718
A substantial proportion of influenza-related childhood deaths are due to infection with influenza B viruses, which co-circulate in the human population as two antigenically distinct lineages defined by the immunodominant...
8.
Paul S, Mok C, Mak T, Ng O, Aboagye J, Wohlbold T, et al.
Antiviral Res
. 2017 Jun;
144:299-310.
PMID: 28633988
The sporadic outbreaks of highly pathogenic H5N1 avian influenza virus have raised public health concerns. Monoclonal antibodies (MAbs) against hemagglutinin (HA) have been increasingly used successfully for therapeutic purposes. Previously,...
9.
Duehr J, Wohlbold T, Oestereich L, Chromikova V, Amanat F, Rajendran M, et al.
J Virol
. 2017 Jun;
91(16).
PMID: 28592526
Out of an estimated 31,100 cases since their discovery in 1976, ebolaviruses have caused approximately 13,000 deaths. The vast majority (∼11,000) of these occurred during the 2013-2016 West African epidemic....
10.
Klausberger M, Tscheliessnig R, Neff S, Nachbagauer R, Wohlbold T, Wilde M, et al.
PLoS One
. 2016 Apr;
11(4):e0153579.
PMID: 27088239
Significant genetic variability in the head region of the influenza A hemagglutinin, the main target of current vaccines, makes it challenging to develop a long-lived seasonal influenza prophylaxis. Vaccines based...