Tatyana I Rokitskaya
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Explore the profile of Tatyana I Rokitskaya including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Rokitskaya T, Khailova L, Strelnik A, Kotova E, Mironov V, Tatarinov D, et al.
Biochim Biophys Acta Biomembr
. 2025 Feb;
1867(3):184417.
PMID: 39983808
2-(2-hydroxyaryl)vinylphosphonium salts are zwitterionic protonophores previously shown to induce proton transport across lipid membranes via cyclic deprotonation and protonation of the hydroxyl group. Here, we examine the impact of the...
2.
Khailova L, Kirsanov R, Rokitskaya T, Krasnov V, Korshunova G, Kotova E, et al.
Biochim Biophys Acta Bioenerg
. 2024 Aug;
1865(4):149506.
PMID: 39168228
Mitochondrial uncoupling by small-molecule protonophores is generally accepted to proceed via transmembrane proton shuttling. The idea of facilitating this process by the adenine nucleotide translocase ANT originated primarily from the...
3.
Antonenko Y, Veselov I, Rokitskaya T, Vinogradova D, Khailova L, Kotova E, et al.
Chem Biol Interact
. 2024 Aug;
402:111190.
PMID: 39121899
The isothiourea derivative NT-1505 is known as a neuroprotector and cognition enhancer in animal models of neurodegenerative diseases. Bearing in mind possible relation of the NT-1505-mediated neuroprotection to mitochondrial uncoupling...
4.
Sokolov S, Smirnova E, Rokitskaya T, Severin F
Biochemistry (Mosc)
. 2024 Apr;
89(3):451-461.
PMID: 38648765
Ionic liquids (ILs) are organic salts with a low melting point. This is due to the fact that their alkyl side chains, which are covalently connected to the ion, hinder...
5.
Kirsanov R, Khailova L, Rokitskaya T, Lyamzaev K, Panteleeva A, Nazarov P, et al.
ACS Omega
. 2024 Mar;
9(10):11551-11561.
PMID: 38496966
Mitochondrial uncouplers are actively sought as potential therapeutics. Here, we report the first successful synthesis of mitochondria-targeted derivatives of the highly potent uncoupler 3,5-di-butyl-4-hydroxybenzylidene-malononitrile (SF6847), bearing a cationic alkyl(triphenyl)phosphonium (TPP)...
6.
Rokitskaya T, Kirsanov R, Khailova L, Panteleeva A, Lyamzaev K, Korshunova G, et al.
Chembiochem
. 2024 Feb;
25(7):e202300848.
PMID: 38353515
We have recently discovered that ester-stabilized phosphorus ylides, resulting from deprotonation of a phosphonium salt such as [Ph3PCH2COOR], can transfer protons across artificial and biological membranes. To create more effective...
7.
Luponosov Y, Solodukhin A, Aseyev N, Rokitskaya T, Kolotova D, Kotova E, et al.
ACS Biomater Sci Eng
. 2024 Jan;
10(2):1139-1152.
PMID: 38241460
Organic semiconductor materials with a unique set of properties are very attractive for interfacing biological objects and can be used for noninvasive therapy or detection of biological signals. Here, we...
8.
Rokitskaya T, Alekseev A, Tsybrov F, Bukhalovich S, Antonenko Y, Gordeliy V
Biochemistry (Mosc)
. 2023 Dec;
88(10):1571-1579.
PMID: 38105025
In this work, TcaR rhodopsin from the cyanobacterium Tolypothrix campylonemoides was characterized. Analysis of the amino acid sequence of TcaR revealed that this protein possesses a TSD motif that differs...
9.
Rokitskaya T, Khailova L, Korshunova G, Antonenko Y
Biochim Biophys Acta Biomembr
. 2023 Jun;
1865(7):184183.
PMID: 37286154
In order to determine the share of protonophoric activity in the uncoupling action of lipophilic cations a number of analogues of butyltriphenylphosphonium with substitutions in phenyl rings (CTPP-X) were studied...
10.
Rokitskaya T, Firsov A, Khailova L, Kotova E, Antonenko Y
Biochim Biophys Acta Biomembr
. 2023 Jun;
1865(7):184182.
PMID: 37276926
The ionophoric antibiotic salinomycin is in the phase of preclinical tests against several types of malignant tumors including breast cancer. Notwithstanding, the data on its ion selectivity, although being critical...