Tatsuya Ohyama
Overview
Explore the profile of Tatsuya Ohyama including associated specialties, affiliations and a list of published articles.
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51
Citations
665
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Recent Articles
1.
Ghosh S, Takahashi S, Ohyama T, Liu L, Sugimoto N
J Am Chem Soc
. 2024 Nov;
146(47):32479-32497.
PMID: 39505325
Hydration plays a key role in the structure-specific stabilization of biomolecules such as nucleic acids. The hydration patterns of biased DNA sequences in the genome, such as GC-repetitive and AT-repetitive...
2.
Banerjee D, Tateishi-Karimata H, Toplishek M, Ohyama T, Ghosh S, Takahashi S, et al.
J Am Chem Soc
. 2023 Oct;
145(43):23503-23518.
PMID: 37873979
In cells, the formation of RNA/DNA hybrid duplexes regulates gene expression and modification. The environment inside cellular organelles is heterogeneously crowded with high concentrations of biomolecules that affect the structure...
3.
Das S, Takahashi S, Ohyama T, Bhowmik S, Sugimoto N
Sci Rep
. 2023 Sep;
13(1):14338.
PMID: 37658102
Ligands that recognise specific i-motif DNAs are helpful in cancer diagnostics and therapeutics, as i-motif formation can cause cancer. Although the loop regions of i-motifs are promising targets for ligands,...
4.
Watanabe C, Tanaka S, Okiyama Y, Yuki H, Ohyama T, Kamisaka K, et al.
J Phys Chem Lett
. 2023 Apr;
14(15):3609-3620.
PMID: 37023394
A non-covalent oral drug targeting SARS-CoV-2 main protease (M), ensitrelvir (Xocova), has been developed using structure-based drug design (SBDD). To elucidate the factors responsible for enhanced inhibitory activities from an...
5.
Ghosh S, Takahashi S, Banerjee D, Ohyama T, Endoh T, Tateishi-Karimata H, et al.
Nucleic Acids Res
. 2023 Jan;
51(9):4101-4111.
PMID: 36718808
RNA performs various spatiotemporal functions in living cells. As the solution environments significantly affect the stability of RNA duplexes, a stability prediction of the RNA duplexes in diverse crowded conditions...
6.
Matsumoto S, Takahashi S, Bhowmik S, Ohyama T, Sugimoto N
Anal Chem
. 2022 May;
94(20):7400-7407.
PMID: 35535999
Hydration around nucleic acids, such as DNA and RNA, is an important factor not only for the stability of nucleic acids but also for their interaction with binding molecules. Thus,...
7.
Matsumoto S, Tateishi-Karimata H, Ohyama T, Sugimoto N
RSC Adv
. 2022 May;
11(59):37205-37217.
PMID: 35496393
Patterns and levels of DNA modifications play important roles in senescence. Two major epigenetic modifications of DNA, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), target CpG sites. Importantly, CpG concentrated regions, known...
8.
Sugimoto W, Kinoshita N, Nakata M, Ohyama T, Tateishi-Karimata H, Nishikata T, et al.
Chem Commun (Camb)
. 2021 Nov;
58(1):48-51.
PMID: 34811561
We identified cytosine-rich regions adjacent to guanine-rich regions in protease genes. A typical GC-rich sequence derived from the gene showed structural competition between a G-quadruplex and a hairpin loop, and...
9.
Banerjee D, Tateishi-Karimata H, Ohyama T, Ghosh S, Endoh T, Takahashi S, et al.
Nucleic Acids Res
. 2021 Sep;
49(18):10796-10799.
PMID: 34520551
No abstract available.
10.
Fukuzawa K, Kato K, Watanabe C, Kawashima Y, Handa Y, Yamamoto A, et al.
J Chem Inf Model
. 2021 Sep;
61(9):4594-4612.
PMID: 34506132
SARS-CoV-2 is the causative agent of coronavirus (known as COVID-19), the virus causing the current pandemic. There are ongoing research studies to develop effective therapeutics and vaccines against COVID-19 using...