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Tatiana Mikheeva

Explore the profile of Tatiana Mikheeva including associated specialties, affiliations and a list of published articles. Areas
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Articles 10
Citations 559
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Recent Articles
1.
Golovina T, Mikheeva T, Brusko T, Blazar B, Bluestone J, Riley J
PLoS One . 2011 Jan; 6(1):e15868. PMID: 21253593
Natural T regulatory cells (Tregs) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. All trans retinoic acid (ATRA) plays an...
2.
Akimova T, Ge G, Golovina T, Mikheeva T, Wang L, Riley J, et al.
Clin Immunol . 2010 May; 136(3):348-63. PMID: 20478744
Histone/protein deacetylases (HDACs) decrease histone and protein acetylation, typically leading to suppression of gene transcription and modulation of various protein functions. We found significant differences in expression of HDAC before...
3.
Golovina T, Mikheeva T, Suhoski M, Aqui N, Tai V, Shan X, et al.
J Immunol . 2008 Aug; 181(4):2855-68. PMID: 18684977
The costimulatory requirements required for peripheral blood T regulatory cells (Tregs) are unclear. Using cell-based artificial APCs we found that CD28 but not ICOS, OX40, 4-1BB, CD27, or CD40 ligand...
4.
Basu S, Golovina T, Mikheeva T, June C, Riley J
J Immunol . 2008 Apr; 180(9):5794-8. PMID: 18424697
Addition of rapamycin to cultures of expanding natural CD4+CD25+Foxp3+ T regulatory cells (Tregs) helps maintain their suppressive activity, but the underlying mechanism is unclear. Pim 2 is a serine/threonine kinase...
5.
Phares T, Kean R, Mikheeva T, Hooper D
J Immunol . 2006 Jun; 176(12):7666-75. PMID: 16751414
The loss of blood-brain barrier (BBB) integrity in CNS inflammatory responses triggered by infection and autoimmunity has generally been associated with the development of neurological signs. In the present study,...
6.
Fedorov V, Li L, Glukhov A, Shishkina I, Aliev R, Mikheeva T, et al.
Heart Rhythm . 2005 Sep; 2(9):966-75. PMID: 16171752
Background: Most mammals experience cardiac arrest during hypothermia. In contrast, hibernators remain in sinus rhythm even at body temperatures of 0 degrees C. Objectives: The purpose of this study was...
7.
Scott G, Kean R, Fabis M, Mikheeva T, Brimer C, Phares T, et al.
J Neuroimmunol . 2004 Sep; 155(1-2):32-42. PMID: 15342194
Urate (UA) selectively scavenges peroxynitrite-dependent radicals and suppresses CNS inflammation through effects that are manifested at the blood-brain barrier (BBB). ICAM-1 upregulation in the spinal cord tissues of myelin basic...
8.
Scott G, Kean R, Mikheeva T, Fabis M, Mabley J, Szabo C, et al.
J Pharmacol Exp Ther . 2004 May; 310(3):1053-61. PMID: 15159442
Poly(ADP-ribose) polymerase (PARP) activity has been implicated in the pathogenesis of several central nervous system (CNS) disorders. For example, the presence of extensive poly(ADP)ribosylation in CNS tissues from animals with...
9.
Scott G, Spitsin S, Kean R, Mikheeva T, Koprowski H, Hooper D
Proc Natl Acad Sci U S A . 2002 Nov; 99(25):16303-8. PMID: 12451183
Uric acid (UA) is a purine metabolite that selectively inhibits peroxynitrite-mediated reactions implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative diseases. Serum UA levels are inversely associated...
10.
Spitsin S, Scott G, Mikheeva T, Zborek A, Kean R, Brimer C, et al.
Free Radic Biol Med . 2002 Nov; 33(10):1363-71. PMID: 12419468
Serum levels of uric acid (UA), an inhibitor of peroxynitrite- (ONOO-) related chemical reactions, became elevated approximately 30 million years ago in hominid evolution. During a similar time frame, higher...