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» Authors » Taro Masunaga

Taro Masunaga

Explore the profile of Taro Masunaga including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 11
Citations 106
Followers 0
Related Specialties
General Surgery
Allergy & Immunology
Biology
Top 10 Co-Authors
Kouichi Tamura
Kenichiro Yamashita
Toshimitsu Uede
Satoru Todo
Taku Hashimoto
Kaori Kubo
Manabu Inobe
Nan Hua
Masaaki Murakami
Miri Fujita
Published In
Transplantation
Int Immunol
Cytokine
Eur J Pharmacol
J Invest Dermatol
Affiliations
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Recent Articles
1.
Absence of Activation-induced Cytidine Deaminase, a Regulator of Class Switch Recombination and Hypermutation in B Cells, Suppresses Aorta Allograft Vasculopathy in Mice
Nakanishi T, Xu X, Wynn C, Yamada T, Pan F, Erickson L, et al.
Transplantation . 2015 Mar; 99(8):1598-605. PMID: 25769064
Background: Antibody-mediated rejection is caused in part by increasing circulation/production of donor-specific antibody (DSA). Activation-induced cytidine deaminase (AID) is a key regulator of class switch recombination and somatic hypermutation of...
2.
In vitro and in vivo characterization of AS2643361, a novel and highly potent inosine 5'-monophosphate dehydrogenase inhibitor
Nakanishi T, Kozuki Y, Eikyu Y, Kubo K, Kawato Y, Marui T, et al.
Eur J Pharmacol . 2011 Nov; 674(1):58-63. PMID: 22075081
Inosine 5'-monophosphate (IMP) dehydrogenase is a critical target in solid organ transplantation. To this end, the development of mycophenolate mofetil (MMF) represents a major advance in transplant medicine. Here, we...
3.
Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours
Piao J, Kamimura Y, Iwai H, Cao Y, Kikuchi K, Hashiguchi M, et al.
Immunology . 2009 Jul; 127(4):489-99. PMID: 19604302
Glucocorticoid-induced tumour necrosis factor receptor-related receptor (GITR) costimulates functions of both effector and regulatory T cells. The administration of agonistic anti-GITR monoclonal antibodies efficiently enhances various T-cell-mediated immune responses; however,...
4.
FR255734, a humanized, Fc-Silent, Anti-CD28 antibody, improves psoriasis in the SCID mouse-psoriasis xenograft model
Raychaudhuri S, Kundu-Raychaudhuri S, Tamura K, Masunaga T, Kubo K, Hanaoka K, et al.
J Invest Dermatol . 2008 Mar; 128(8):1969-76. PMID: 18337836
In psoriasis, CD28/B7 costimulatory molecules are well characterized. Here, using the severe combined immunodeficient (SCID) mouse-psoriasis xenograft model, we report therapeutic efficacy of a humanized anti-CD28 monoclonal antibody (FR255734; Astellas...
5.
Immunomodulatory properties of FK734, a humanized anti-CD28 monoclonal antibody with agonistic and antagonistic activities
Shiao S, McNiff J, Masunaga T, Tamura K, Kubo K, Pober J
Transplantation . 2007 Feb; 83(3):304-13. PMID: 17297405
Background: We describe immunomodulatory effects of FK734, a humanized version of a mouse anti-human CD28 mAb (clone TN228), in vitro and in a chimeric human-mouse model of allograft rejection. Methods:...
6.
Dimeric but not monomeric soluble CD40 prolongs allograft survival and generates regulatory T cells that inhibit CTL function
Masunaga T, Yamashita K, Sakihama H, Hashimoto T, Hua N, Imai A, et al.
Transplantation . 2005 Dec; 80(11):1614-22. PMID: 16371933
Background: We previously reported that adenovirus mediated CD40Ig gene therapy (AdCD40Ig) induced long-term acceptance of fully allogeneic rat cardiac allografts, however, the underlying mechanism has not been fully clarified. To...
7.
Gene therapy-mediated CD40L and CD28 co-stimulatory signaling blockade plus transient anti-xenograft antibody suppression induces long-term acceptance of cardiac xenografts
Hua N, Yamashita K, Hashimoto T, Masunaga T, Fujita M, Furukawa H, et al.
Transplantation . 2004 Dec; 78(10):1463-70. PMID: 15599310
Background: The authors have previously demonstrated that inhibition of CD28 and CD40 ligand (CD40L) co-stimulatory signals by adenovirus-mediated cytotoxic T-lymphocyte-associated (CTL) antigen 4 (A4) immunoglobulin (Ig) and CD40Ig gene therapies...
8.
FK506 suppresses E-selectin, ICAM-1 and VCAM-1 expression on vascular endothelial cells by inhibiting tumor necrosis factor alpha secretion from peripheral blood mononuclear cells
Sasakawa T, Sasakawa Y, Masunaga T, Fujitsu T, Hirayama Y, Ohkubo Y, et al.
Cytokine . 2004 Dec; 29(2):67-71. PMID: 15598440
FK506 suppresses activation of T cells; however, it down-regulates E-selectin, ICAM-1 and VCAM-1 expression in inflamed tissues. In this study, we investigated the effect of FK506 on expression of those...
9.
Stromal cell-derived factor-1 and CXCR4 interaction is critical for development of transplant arteriosclerosis
Sakihama H, Masunaga T, Yamashita K, Hashimoto T, Inobe M, Todo S, et al.
Circulation . 2004 Oct; 110(18):2924-30. PMID: 15505104
Background: Posttransplant chronic allograft deterioration associated with development of transplant arteriosclerosis (TA) remains an unresolved problem. Recent studies suggest that the smooth muscle cells (SMCs) constituting the neointima are derived...
10.
Long-term acceptance of rat cardiac allografts on the basis of adenovirus mediated CD40Ig plus CTLA4Ig gene therapies
Yamashita K, Masunaga T, Yanagida N, Takehara M, Hashimoto T, Kobayashi T, et al.
Transplantation . 2003 Oct; 76(7):1089-96. PMID: 14557758
Background: We have previously demonstrated that blockade of either CD80/86-CD28 or CD40-CD154 costimulatory pathways by using adenovirus vector coding CTLA4Ig (AdCTLA4Ig) or CD40Ig (AdCD40Ig) genes induced donor-specific tolerance in rat...