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Tarana Siddika

Explore the profile of Tarana Siddika including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 54
Followers 0
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Recent Articles
1.
Siddika T, Shao R, Heinemann I, ODonoghue P
IUBMB Life . 2024 May; 76(9):632-646. PMID: 38738523
Protein kinase B (AKT1) is a serine/threonine kinase that regulates fundamental cellular processes, including cell survival, proliferation, and metabolism. AKT1 activity is controlled by two regulatory phosphorylation sites (Thr308, Ser473)...
2.
Siddika T, Balasuriya N, Frederick M, Rozik P, Heinemann I, ODonoghue P
Cells . 2022 Dec; 11(23). PMID: 36497091
Protein kinase B (AKT1) is a serine/threonine kinase and central transducer of cell survival pathways. Typical approaches to study AKT1 biology in cells rely on growth factor or insulin stimulation...
3.
Wright D, Siddika T, Heinemann I, ODonoghue P
Front Mol Biosci . 2022 Oct; 9:1031756. PMID: 36304926
Over-expression of genetically encoded thioredoxin reductase 1 (TrxR1) TrxR1 can be toxic to cells due to the formation of a truncated version of the enzyme. We developed a new mammalian...
4.
Siddika T, Heinemann I, ODonoghue P
Elife . 2022 May; 11. PMID: 35543705
Engineering transfer RNAs to read codons consisting of four bases requires changes in tRNA that go beyond the anticodon sequence.
5.
Frederick M, Siddika T, Zhang P, Balasuriya N, Turk M, ODonoghue P, et al.
Cells . 2022 Mar; 11(5). PMID: 35269443
The phosphoinositide-3-kinase (PI3K)/AKT pathway regulates cell survival and is over-activated in most human cancers, including ovarian cancer. Following growth factor stimulation, AKT1 is activated by phosphorylation at T308 and S473....
6.
Chung C, Balasuriya N, Siddika T, Frederick M, Heinemann I
RNA Biol . 2021 Jul; 18(sup1):397-408. PMID: 34288801
In the cell, RNA abundance is dynamically controlled by transcription and decay rates. Posttranscriptional nucleotide addition at the RNA 3' end is a means of regulating mRNA and RNA stability...
7.
Siddika T, Heinemann I
Front Bioeng Biotechnol . 2021 Feb; 8:619583. PMID: 33537295
MiRNAs are small non-coding RNAs that interact with their target mRNAs for posttranscriptional gene regulation. Finely controlled miRNA biogenesis, target recognition and degradation indicate that maintaining miRNA homeostasis is essential...