Tanya Keenan
Overview
Explore the profile of Tanya Keenan including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
662
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0
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Recent Articles
1.
Shapira-Frommer R, Niu J, Perets R, Peters S, Shouse G, Lugowska I, et al.
Future Oncol
. 2024 Sep;
20(27):1983-1991.
PMID: 39230120
Vibostolimab, a humanized IgG1 monoclonal antibody, blocks the interaction between TIGIT and its ligands, preventing the immunosuppressive effects of TIGIT. The addition of vibostolimab to the PD-1 inhibitor pembrolizumab has...
2.
Barroso-Sousa R, Forman J, Collier K, Weber Z, Jammihal T, Kao K, et al.
JCO Precis Oncol
. 2022 Jul;
6:e2100413.
PMID: 35797509
Purpose: In metastatic triple-negative breast cancer (mTNBC), consistent biomarkers of immune checkpoint inhibitor (ICI) therapy benefit remain elusive. We evaluated the immune, genomic, and transcriptomic landscape of mTNBC in patients...
3.
Reardon B, Moore N, Moore N, Kofman E, AlDubayan S, Cheung A, et al.
Nat Cancer
. 2022 Feb;
2(10):1102-1112.
PMID: 35121878
Tumor molecular profiling of single gene-variant ('first-order') genomic alterations informs potential therapeutic approaches. Interactions between such first-order events and global molecular features (for example, mutational signatures) are increasingly associated with...
4.
Goldberg J, Pastorello R, Vallius T, Davis J, Cui Y, Agudo J, et al.
Front Immunol
. 2021 Jun;
12:674192.
PMID: 34135901
Immune checkpoint blockade (ICB) has revolutionized the treatment of cancer patients. The main focus of ICB has been on reinvigorating the adaptive immune response, namely, activating cytotoxic T cells. ICB...
5.
Conway J, Dietlein F, Taylor-Weiner A, AlDubayan S, Vokes N, Keenan T, et al.
Nat Genet
. 2020 Nov;
52(12):1373-1383.
PMID: 33230298
We performed harmonized molecular and clinical analysis on 1,048 melanomas and discovered markedly different global genomic properties among subtypes (BRAF, (N)RAS, NF1, triple wild-type (TWT)), subtype-specific preferences for secondary driver...
6.
Tolaney S, Barroso-Sousa R, Keenan T, Li T, Trippa L, Vaz-Luis I, et al.
JAMA Oncol
. 2020 Sep;
6(10):1598-1605.
PMID: 32880602
Importance: Prior studies have shown that only a small proportion of patients with hormone receptor (HR)-positive metastatic breast cancer (MBC) experience benefit from programmed cell death 1 (PD-1)/programmed cell death...
7.
El-Jawahri A, Keenan T, Abel G, Steensma D, LeBlanc T, Chen Y, et al.
Lancet Haematol
. 2016 Jun;
3(6):e276-83.
PMID: 27264037
Background: Older adults (≥60 years of age) with acute myeloid leukaemia spend a substantial proportion of their life in hospital after diagnosis. We examined reasons for their hospital admissions and...
8.
Keenan T, Zhao W, Rasheed A, Ho W, Malik R, Felix J, et al.
J Am Coll Cardiol
. 2016 Jan;
67(4):407-416.
PMID: 26821629
Background: Although epidemiological studies have reported positive associations between circulating urate levels and cardiometabolic diseases, causality remains uncertain. Objectives: Through a Mendelian randomization approach, we assessed whether serum urate levels...
9.
El-Jawahri A, Vandusen H, Traeger L, Fishbein J, Keenan T, Gallagher E, et al.
Cancer
. 2015 Dec;
122(5):806-12.
PMID: 26650840
Background: During hospitalization for hematopoietic stem cell transplantation (HCT), patients experience a steep deterioration in quality of life (QOL) and mood. To our knowledge, the impact of this deterioration on...
10.
Keenan T, Moy B, Mroz E, Ross K, Niemierko A, Rocco J, et al.
J Clin Oncol
. 2015 Sep;
33(31):3621-7.
PMID: 26371147
Purpose: African American women are more likely to die as a result of breast cancer than white women. The influence of somatic genomic profiles on this racial disparity is unclear....