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Tammy L McGuire

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Recent Articles
1.
Andrade da Silva L, Heuer R, Roque C, McGuire T, Hosoya T, Kimura H, et al.
Stem Cell Res Ther . 2023 Apr; 14(1):83. PMID: 37046329
Stem cell replacement holds the potential for sensorineural hearing loss (SNHL) treatment. However, its translation into clinical practice requires strategies for improving stem cell survival following intracochlear transplantation. Considering recent...
2.
Rawat R, Tunc-Ozcan E, McGuire T, Peng C, Kessler J
Nat Commun . 2022 May; 13(1):2650. PMID: 35551462
Ketamine treatment decreases depressive symptoms within hours, but the mechanisms mediating these rapid antidepressant effects are unclear. Here, we demonstrate that activity of adult-born immature granule neurons (ABINs) in the...
3.
Tunc-Ozcan E, Brooker S, Bonds J, Tsai Y, Rawat R, McGuire T, et al.
Cell Mol Life Sci . 2021 Dec; 79(1):31. PMID: 34936033
The benefits of current treatments for depression are limited by low response rates, delayed therapeutic effects, and multiple side effects. Antidepressants affect a variety of neurotransmitter systems in different areas...
4.
Heuer R, Nella K, Chang H, Coots K, Oleksijew A, Roque C, et al.
Tissue Eng Part A . 2020 Jun; 27(3-4):256-269. PMID: 32580647
Stem cell-replacement therapies have been proposed as a potential tool to treat sensorineural hearing loss by aiding the regeneration of spiral ganglion neurons (SGNs) in the inner ear. However, transplantation...
5.
Chang H, Heuer R, Oleksijew A, Coots K, Roque C, Nella K, et al.
Acta Biomater . 2020 Mar; 108:111-127. PMID: 32156626
Although the application of human embryonic stem cells (hESCs) in stem cell-replacement therapy remains promising, its potential is hindered by a low cell survival rate in post-transplantation within the inner...
6.
Kan C, Yang J, Na D, Xu Y, Yang B, Zhao H, et al.
Bone Res . 2019 Nov; 7:33. PMID: 31700694
Heterotopic ossification (HO), true bone formation in soft tissue, is closely associated with abnormal injury/immune responses. We hypothesized that a key underlying mechanism of HO might be injury-induced dysregulation of...
7.
Cooper J, Sicard D, Sharma S, Van Gulden S, McGuire T, Cajiao M, et al.
J Neurotrauma . 2019 Sep; 37(3):494-506. PMID: 31516087
Gliosis and fibrosis after spinal cord injury (SCI) lead to formation of a scar that is thought to present both molecular and mechanical barriers to neuronal regeneration. The scar consists...
8.
Kan C, Ding N, Yang J, Tan Z, McGuire T, Lu H, et al.
Stem Cell Res Ther . 2019 Jan; 10(1):14. PMID: 30635039
Background: Heterotopic ossification (HO), either acquired (aHO) or hereditary, such as fibrodysplasia ossificans progressiva (FOP), is a serious condition without effective treatment. Understanding of the core process of injury-induced HO...
9.
Cooper J, Jeong S, McGuire T, Sharma S, Wang W, Bhattacharyya S, et al.
Neurobiol Dis . 2018 Apr; 116:60-68. PMID: 29705186
Gliosis and fibrosis after spinal cord injury (SCI) lead to formation of a scar that is an impediment to axonal regeneration. Fibrotic scarring is characterized by the accumulation of fibronectin,...
10.
Chen J, Van Gulden S, McGuire T, Fleming A, Oka C, Kessler J, et al.
J Neurosci . 2018 Feb; 38(15):3840-3857. PMID: 29483282
Astrocytes perform a wide array of physiological functions, including structural support, ion exchange, and neurotransmitter uptake. Despite this diversity, molecular markers that label subpopulations of astrocytes are limited, and mechanisms...