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Tamara Roitbak

Explore the profile of Tamara Roitbak including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 605
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Recent Articles
1.
Carlson A, McKay W, Edwards J, Swaminathan R, SantaCruz K, Mims R, et al.
Genes (Basel) . 2021 Dec; 12(12). PMID: 34946809
Background: Signaling pathways mediated by microRNAs (miRNAs) have been identified as one of the mechanisms that regulate stroke progression and recovery. Recent investigations using stroke patient blood and cerebrospinal fluid...
2.
Roitbak T
Neurochem Res . 2019 Mar; 45(1):188-203. PMID: 30877519
microRNAs (miRNAs) are recently identified small RNA molecules that regulate gene expression and significantly influence the essential cellular processes associated with CNS repair after trauma and neuropathological conditions including stroke...
3.
Pena-Philippides J, Gardiner A, Caballero-Garrido E, Pan R, Zhu Y, Roitbak T
J Am Heart Assoc . 2018 Jun; 7(13). PMID: 29945912
Background: Brain microvascular endothelial cells form a highly selective blood brain barrier regulated by the endothelial tight junctions. Cerebral ischemia selectively targets tight junction protein complexes, which leads to significant...
4.
Roitbak T
Front Mol Neurosci . 2018 Mar; 11:58. PMID: 29527155
Stroke-induced endothelial cell injury leads to destruction of cerebral microvasculature and significant damage to the brain tissue. A subacute phase of cerebral ischemia is associated with regeneration involving the activation...
5.
Pena-Philippides J, Caballero-Garrido E, Lordkipanidze T, Roitbak T
J Neuroinflammation . 2016 Nov; 13(1):287. PMID: 27829437
Background: MicroRNA miR-155 is implicated in modulation of the inflammatory processes in various pathological conditions. In our previous studies, we demonstrated that in vivo inhibition of miR-155 promotes functional recovery...
6.
Caballero-Garrido E, Pena-Philippides J, Lordkipanidze T, Bragin D, Yang Y, Erhardt E, et al.
J Neurosci . 2015 Sep; 35(36):12446-64. PMID: 26354913
A multifunctional microRNA, miR-155, has been recently recognized as an important modulator of numerous biological processes. In our previous in vitro studies, miR-155 was identified as a potential regulator of...
7.
Jalal F, Yang Y, Thompson J, Roitbak T, Rosenberg G
J Cereb Blood Flow Metab . 2015 Feb; 35(7):1145-53. PMID: 25712499
Hypertensive small vessel disease is a major cause of vascular cognitive impairment (VCI). Spontaneously hypertensive/stroke prone rats (SHR/SP) with unilateral carotid artery occlusion (UCAO) and a Japanese permissive diet (JPD)...
8.
Pena-Philippides J, Yang Y, Bragina O, Hagberg S, Nemoto E, Roitbak T
Transl Stroke Res . 2014 Feb; 5(4):491-500. PMID: 24549571
Pulsed electromagnetic fields (PEMF) have been demonstrated to have anti-inflammatory and pro-regenerative effects in animals and humans. We used the FDA-approved Sofpulse (Ivivi Health Sciences, LLC) to study effect of...
9.
Roitbak T, Bragina O, Padilla J, Pickett G
Vasc Cell . 2011 Nov; 3:25. PMID: 22071092
Functional signaling between neural stem/progenitor cells (NSPCs) and brain endothelial cells (ECs) is essential to the coordination of organized responses during initial embryonic development and also during tissue repair, which...
10.
Roitbak T, Thomas K, Martin A, Allan A, Cunningham L
Exp Neurol . 2011 Mar; 229(2):522-5. PMID: 21419122
Gestational alcohol exposure leads to a spectrum of neurological symptoms which range from severe mental retardation caused by high dose exposure, to subtle cognitive and neuropsychiatric symptoms caused by low-to-moderate...