Tam T T N Nguyen
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Explore the profile of Tam T T N Nguyen including associated specialties, affiliations and a list of published articles.
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16
Citations
78
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Recent Articles
1.
Wu S, Nguyen T, Moroz O, Turkenburg J, Nielsen J, Wilson K, et al.
PeerJ
. 2020 Jul;
8:e9408.
PMID: 32617193
Background: Several examples have emerged of enzymes where slow conformational changes are of key importance for function and where low populated conformations in the resting enzyme resemble the conformations of...
2.
Fogh J, Jacobsen A, Nguyen T, Rand K, Olsen L
Anal Bioanal Chem
. 2020 Feb;
412(7):1653-1661.
PMID: 32008082
As quantitative analysis of biotherapeutics in cerebrospinal fluid (CSF) with LC-MS becomes increasingly widespread, there is a need for method developments towards higher sensitivity. By using artificial CSF (aCSF) in...
3.
Hermida D, Mortuza G, Pedersen A, Pozdnyakova I, Nguyen T, Maroto M, et al.
Mol Cell Proteomics
. 2019 Dec;
19(2):326-343.
PMID: 31852836
The human MASTL (Microtubule-associated serine/threonine kinase-like) gene encodes an essential protein in the cell cycle. MASTL is a key factor preventing early dephosphorylation of M-phase targets of Cdk1/CycB. Little is...
4.
Dorosz J, Kristensen L, Aduri N, Mirza O, Lousen R, Bucciarelli S, et al.
Sci Rep
. 2019 Mar;
9(1):4019.
PMID: 30858420
The full length human histone 3 lysine 4 demethylase KDM5B (PLU-1/Jarid1B) has been studied using Hydrogen/Deuterium exchange mass spectrometry, homology modelling, sequence analysis, small angle X-ray scattering and electron microscopy....
5.
Johansen N, Tidemand F, Nguyen T, Rand K, Pedersen M, Arleth L
FEBS J
. 2019 Jan;
286(9):1734-1751.
PMID: 30675761
Recently, an enzymatic reaction was utilized to covalently link the N and C termini of membrane scaffold proteins to produce circularized nanodiscs that were more homogeneous and stable than standard...
6.
Nguyen T, Mistarz U, Costa N, Herbet A, Boquet D, Becher F, et al.
J Pharm Biomed Anal
. 2018 Aug;
159:384-392.
PMID: 30071466
Determination of the pharmacokinetic (PK) properties of therapeutic monoclonal antibodies (mAbs) is essential for their successful development as drugs. For this purpose, besides the traditional ligand binding assay (LBA), LC-MS/MS...
7.
Stiefler-Jensen D, Schwarz-Linnet T, de Lichtenberg C, Nguyen T, Rand K, Huang L, et al.
Protein Sci
. 2017 Jul;
26(9):1819-1827.
PMID: 28681456
Enzymes from thermophilic and hyper-thermophilic organisms have an intrinsic high stability. Understanding the mechanisms behind their high stability will be important knowledge for the engineering of novel enzymes with high...
8.
Mistarz U, Singh S, Nguyen T, Roeffen W, Yang F, Lissau C, et al.
Pharm Res
. 2017 Jun;
34(9):1970-1983.
PMID: 28646324
Purpose: Production and characterization of a chimeric fusion protein (GMZ2'.10C) which combines epitopes of key malaria parasite antigens: glutamate-rich protein (GLURP), merozoite surface protein 3 (MSP3), and the highly disulphide...
9.
Jonsson A, Svejdal R, Bogelund N, Nguyen T, Flindt H, Kutter J, et al.
Anal Chem
. 2017 Mar;
89(8):4573-4580.
PMID: 28322047
To improve the sample handling, and reduce cost and preparation time, of peptide mapping LC-MS workflows in protein analytical research, we here investigate the possibility of replacing conventional enzymatic digestion...
10.
Nguyen T, Petersen N, Rand K
Anal Chim Acta
. 2016 Aug;
936:157-67.
PMID: 27566351
Online coupling of capillary electrophoresis (CE) to electrospray ionization mass spectrometry (MS) has shown considerable potential, however, technical challenges have limited its use. In this study, we have developed a...