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Takumi Tomohiro

Explore the profile of Takumi Tomohiro including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 18
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Recent Articles
1.
Nishisaka H, Tomohiro T, Fukuzumi K, Fukao A, Funakami Y, Fujiwara T
Biochimie . 2024 Jan; 221:20-26. PMID: 38244852
The RNA-binding protein HuD/ELAVL4 is essential for neuronal development and synaptic plasticity by governing various post-transcriptional processes of target mRNAs, including stability, translation, and localization. We previously showed that the...
2.
Nishisaka H, Tomohiro T, Fukao A, Funakami Y, Fujiwara T
Biol Pharm Bull . 2023 Feb; 46(2):158-162. PMID: 36724943
Translation initiation is the rate-limiting step of protein synthesis and is the main target of translation regulation. RNA-binding proteins (RBPs) are key mediators of the spatiotemporal control of translation and...
3.
Suzuki T, Hoshina M, Nishijima S, Hoshina N, Kikuguchi C, Tomohiro T, et al.
RNA Biol . 2022 Feb; 19(1):234-246. PMID: 35129087
CCR4-NOT complex-mediated mRNA deadenylation serves critical functions in multiple biological processes, yet how this activity is regulated is not fully understood. Here, we show that osmotic stress induces MAPKAPK-2 (MK2)-mediated...
4.
Fukao A, Tomohiro T, Fujiwara T
Cells . 2021 Aug; 10(7). PMID: 34359885
Protein synthesis is tightly regulated at each step of translation. In particular, the formation of the basic cap-binding complex, eukaryotic initiation factor 4F (eIF4F) complex, on the 5' cap structure...
5.
Otsuka H, Fukao A, Tomohiro T, Adachi S, Suzuki T, Takahashi A, et al.
Biochimie . 2020 Apr; 174:49-56. PMID: 32311426
Eukaryotic gene expression can be spatiotemporally tuned at the post-transcriptional level by cis-regulatory elements in mRNA sequences. An important example is the AU-rich element (ARE), which induces mRNA destabilization in...