Takeshi Ike
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Explore the profile of Takeshi Ike including associated specialties, affiliations and a list of published articles.
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10
Citations
108
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Recent Articles
1.
Shinkai Y, Sasaki K, Tamura R, Ike T, Takahashi A, Osaki Y, et al.
Sci Rep
. 2024 Oct;
14(1):23816.
PMID: 39394435
Peritoneal inflammation and fibrosis remain major challenges to the long-term maintenance of peritoneal dialysis. Pemafibrate, a selective peroxisome proliferator-activated receptor α (PPARα) modulator, has been implicated in the management of...
2.
Nakayama S, Sun J, Horikoshi Y, Kamimura Y, Ike T, Fujino S, et al.
J Biochem
. 2023 Jan;
173(5):375-382.
PMID: 36634373
Klotho is an anti-aging, single-pass transmembrane protein found mainly in the kidney. Although aging is likely to be associated with DNA damage, the involvement of Klotho in protecting cells from...
3.
Shirai Y, Miura K, Ike T, Sasaki K, Ishizuka K, Horita S, et al.
Kidney Int Rep
. 2022 Dec;
7(11):2431-2445.
PMID: 36531887
Introduction: Neutral-pH dialysate has been reported to be beneficial to prevent the peritoneal pathological changes in adult peritoneal dialysis (PD) patients, but its use is controversial in pediatric PD patients....
4.
Ike T, Doi S, Nakashima A, Sasaki K, Ishiuchi N, Asano T, et al.
Am J Physiol Renal Physiol
. 2022 Sep;
323(5):F539-F552.
PMID: 36074918
The transcription factors hypoxia-inducible factor-1α and -2α (HIF-1α/2α) are the major regulators of the cellular response to hypoxia and play a key role in renal fibrosis associated with acute and...
5.
Matsumoto T, Doi S, Nakashima A, Ike T, Sasaki K, Masaki T
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35887178
The ischemia-reperfusion injury (IRI) of rat kidneys is used as a model of acute kidney injury. Salt-sensitive hypertension occurs in rats after IRI, and the distal nephrons play important roles...
6.
Fujino S, Sun J, Nakayama S, Horikoshi Y, Kinugasa Y, Ishida M, et al.
Radiat Res
. 2022 Jan;
197(4):384-395.
PMID: 35090038
Contrast media has been shown to induce nephropathy (i.e., contrast-induced nephropathy) after various types of radiological examinations. The molecular mechanism of contrast-induced nephropathy has been unclear. In this study, we...
7.
Oishi H, Doi S, Nakashima A, Ike T, Maeoka Y, Sasaki K, et al.
Am J Physiol Renal Physiol
. 2021 Nov;
321(6):F799-F811.
PMID: 34779262
Klotho is an antiaging protein reported to suppress transforming growth factor-β1 (TGF-β1) signaling. Aging kidneys are characterized by interstitial fibrosis, accumulation of cell cycle-arrested cells, and increased levels of oxidative...
8.
Urabe A, Doi S, Nakashima A, Ike T, Morii K, Sasaki K, et al.
PLoS One
. 2021 Oct;
16(10):e0258856.
PMID: 34673800
Hypoxia is a common pathway to the progression of end-stage kidney disease. Retinoic acid-inducible gene I (RIG-I) encodes an RNA helicase that recognizes viruses including SARS-CoV2, which is responsible for...
9.
Kanai R, Nakashima A, Doi S, Kimura T, Yoshida K, Maeda S, et al.
Sci Rep
. 2021 Jan;
11(1):850.
PMID: 33441701
Mesenchymal stem cells (MSCs) administered for therapeutic purposes can be activated by interferon-γ (IFN-γ) secreted from natural killer cells in injured tissues and exert anti-inflammatory effects. These processes require a...
10.
Ishiuchi N, Nakashima A, Doi S, Yoshida K, Maeda S, Kanai R, et al.
Stem Cell Res Ther
. 2020 Mar;
11(1):130.
PMID: 32197638
Background: Mesenchymal stem cells (MSCs) have been reported to promote the regeneration of injured tissue via their paracrine abilities, which are enhanced by hypoxic preconditioning. In this study, we examined...