Takayuki Tsukuba
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Explore the profile of Takayuki Tsukuba including associated specialties, affiliations and a list of published articles.
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82
Citations
3724
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Recent Articles
1.
Sakai E, Tsukuba T
Antioxidants (Basel)
. 2025 Jan;
13(12.
PMID: 39765903
Although osteoclasts play crucial roles in the skeletal system, the mechanisms that underlie oxidative stress during osteoclastogenesis remain unclear. The transcription factor Nrf2 and its suppressor, Keap1, function as central...
2.
Yamaguchi Y, Kadowaki T, Sakai E, Noguromi M, Oyakawa S, Tsukuba T
Biomedicines
. 2024 Nov;
12(11).
PMID: 39595070
Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by immune cell-mediated joint inflammation and subsequent osteoclast-dependent bone destruction. Collagen antibody-induced arthritis (CAIA) is a useful mouse model for examining...
3.
Koyanagi Y, Sakai E, Yamaguchi Y, Farhana F, Taira Y, Okamoto K, et al.
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39519032
Osteoclasts are bone-resorbing multinucleated giant cells formed by the fusion of monocyte/macrophage lineages. Various small GTPases are involved in the multinucleation and differentiation of osteoclasts. However, the roles of small...
4.
Sakai E, Saito M, Koyanagi Y, Takayama Y, Farhana F, Yamaguchi Y, et al.
Cells
. 2024 Nov;
13(21.
PMID: 39513873
Rufy4, a protein belonging to the RUN and FYVE domain-containing protein family, participates in various cellular processes such as autophagy and intracellular trafficking. However, its role in osteoclast-mediated bone resorption...
5.
Htike K, Yoshida K, Eguchi T, Takebe K, Li X, Qu Y, et al.
J Oral Biosci
. 2024 Oct;
66(4):49-57.
PMID: 39366652
Objectives: Osteoporosis is a systemic bone metabolism disorder characterized by decreased bone mass and strength. Osteoclasts (OCs) are giant multinucleated cells that regulate bone homeostasis by degrading bone matrix. Excessive...
6.
Sato K, Kadowaki T, Takenaka M, Konishi M, Ando M, Onodera T, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Jun;
1870(7):167310.
PMID: 38901651
The pancreas is a glandular organ with both endocrine and exocrine functions. Researchers have investigated the roles of several Rab proteins, which are major regulators of membrane trafficking, in pancreatic...
7.
Tanimoto A, Yamaguchi Y, Kadowaki T, Sakai E, Oyakawa S, Ono Y, et al.
J Cell Biochem
. 2023 Aug;
124(10):1486-1502.
PMID: 37566644
Skeletal muscle is composed of multinucleated myotubes formed by the fusion of mononucleated myoblasts. Skeletal muscle differentiation, termed as myogenesis, have been investigated using the mouse skeletal myoblast cell line...
8.
Oyakawa S, Yamaguchi Y, Kadowaki T, Sakai E, Noguromi M, Tanimoto A, et al.
J Cell Physiol
. 2023 Aug;
238(10):2253-2266.
PMID: 37565627
The skeletal muscle is a tissue that shows remarkable plasticity to adapt to various stimuli. The development and regeneration of skeletal muscles are regulated by numerous molecules. Among these, we...
9.
Farhana F, Sakai E, Koyanagi Y, Yamaguchi Y, Alam M, Okamoto K, et al.
Mol Biol Rep
. 2023 Jul;
50(9):7557-7569.
PMID: 37507586
Background: Osteoclasts are multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage lineage. During osteoclast differentiation, Rho GTPases are involved in various processes, including cell migration, adhesion, and polarity. However,...
10.
Kondo Y, Ohara K, Fujii R, Nakai Y, Sato C, Naito M, et al.
Front Cell Infect Microbiol
. 2023 Feb;
13:1095919.
PMID: 36844397
Bacteria of the family (flavobacteria) primarily comprise nonpathogenic bacteria that inhabit soil and water (both marine and freshwater). However, some bacterial species in the family, including and , are known...