Takashi Tominaga
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Explore the profile of Takashi Tominaga including associated specialties, affiliations and a list of published articles.
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81
Citations
1247
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Recent Articles
1.
Tsukuda K, Tominaga Y, Taketoshi M, Miwa M, Nakashima K, Tominaga T
eNeuro
. 2025 Jan;
12(1).
PMID: 39746809
Cuprizone (CPZ) is a widely used toxin that induces demyelinating diseases in animal models, producing multiple sclerosis (MS)-like pathology in rodents. CPZ is one of the few toxins that triggers...
2.
Ojima D, Tominaga Y, Kubota T, Tada A, Takahashi H, Kishimoto Y, et al.
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273620
The maintenance of proper brain function relies heavily on the balance of excitatory and inhibitory neural circuits, governed in part by synaptic adhesion molecules. Among these, MDGA1 (MAM domain-containing glycosylphosphatidylinositol...
3.
Ryu S, Nakashima H, Tanaka Y, Mukai R, Ishihara Y, Tominaga T, et al.
Biomolecules
. 2024 Aug;
14(8).
PMID: 39199272
Mouse double minute 2 (MDM2) is an oncoprotein that is frequently overexpressed in tumors and enhances cellular transformation. Owing to the important role of MDM2 in modulating p53 function, it...
4.
Kandabashi D, Kawano M, Izutani S, Harada H, Tominaga T, Hori M
J Eukaryot Microbiol
. 2024 Aug;
71(6):e13057.
PMID: 39198998
When mechanical stimulation was applied to free swimming Paramecium, forward swimming velocity transiently increased due to activation of the posterior mechanosensory channels. The behavior response, known as "escape response," requires...
5.
Sakoshita K, Aratani S, Kameda N, Takebe R, Tominaga T, Ishida M, et al.
J Eukaryot Microbiol
. 2024 May;
71(4):e13030.
PMID: 38757880
Paramecium exhibits responsive behavior to environmental changes, moving either closer to or further away from stimuli. Electrophysiological experiments have revealed that these behavioral responses are controlled by membrane potentials. Anoctamin,...
6.
Namba K, Tominaga T, Ishihara Y
Environ Toxicol
. 2024 Apr;
39(7):3944-3955.
PMID: 38581179
Neonicotinoids are insecticides widely used in the world. Although neonicotinoids are believed to be toxic only to insects, their developmental neurotoxicity in mammals is a concern. Therefore, we examined the...
7.
Kanayama H, Tominaga T, Tominaga Y, Kato N, Yoshimura H
J Physiol Sci
. 2024 Mar;
74(1):16.
PMID: 38475711
The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABA receptors in network oscillation...
8.
Gusain P, Taketoshi M, Tominaga Y, Tominaga T
eNeuro
. 2023 Nov;
10(12).
PMID: 37977827
Prefrontal cortex (PFC) intrahemispheric activity and the interhemispheric connection have a significant impact on neuropsychiatric disorder pathology. This study aimed to generate a functional map of FC intrahemispheric and interhemispheric...
9.
Hori M, Tominaga T, Ishida M, Kawano M
Biophys Physicobiol
. 2023 Oct;
20(2):e200025.
PMID: 37867561
In , a mechanical stimulus applied to the posterior portion of the cell causes a transient increase in membrane permeability to potassium ions, transiently rendering the membrane in a hyperpolarized...
10.
Utsumi Y, Taketoshi M, Miwa M, Tominaga Y, Tominaga T
Front Cell Neurosci
. 2023 Sep;
17:1217368.
PMID: 37680865
Non-clinical toxicology is a major cause of drug candidate attrition during development. In particular, drug-induced seizures are the most common finding in central nervous system (CNS) toxicity. Current safety pharmacology...