Takashi I
Overview
Explore the profile of Takashi I including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
148
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Recent Articles
1.
I T, Kanai R, Hasegawa K, Ogaeri T, Tran S, Sumita Y
Oral Dis
. 2023 Jul;
30(1):38-49.
PMID: 37498953
Objective: For functional restoration of salivary glands (SGs) injured by radiation therapy or Sjögren's syndrome (SS), various experimental approaches, such as gene therapy, tissue engineering, and cell-based therapy, have been...
2.
Honma R, I T, Seki M, Iwatake M, Ogaeri T, Hasegawa K, et al.
Cells
. 2023 Jul;
12(10).
PMID: 37408251
A newly developed therapy using effective-mononuclear cells (E-MNCs) is reportedly effective against radiation-damaged salivary glands (SGs) due to anti-inflammatory and revascularization effects. However, the cellular working mechanism of E-MNC therapy...
3.
Hasegawa K, Montenegro Raudales J, I T, Yoshida T, Honma R, Iwatake M, et al.
Front Bioeng Biotechnol
. 2023 May;
11:1144624.
PMID: 37168614
Sjögren syndrome (SS) is an autoimmune disease characterized by salivary gland (SG) destruction leading to loss of secretory function. A hallmark of the disease is the presence of focal lymphocyte...
4.
I T, Noda S, Ohba S, Asahina I, Sumita Y
Medicines (Basel)
. 2023 Jan;
10(1).
PMID: 36662493
We have recently proposed an alternative strategy of free gingival graft (FGG) and connective tissue graft (CTG) using micronized-gingival connective tissues (MGCTs). The advantage of this strategy is that MGCTs...
5.
I T, Ueda Y, Worsdorfer P, Sumita Y, Asahina I, Ergun S
J Neural Transm (Vienna)
. 2020 Oct;
127(11):1467-1479.
PMID: 33025085
Salivary gland (SG) hypofunction is a common post-radiotherapy complication. Besides the parenchymal damage after irradiation (IR), there are also effects on mesenchymal stem cells (MSCs) which were shown to contribute...
6.
Kawamura H, Watanabe S, I T, Asahina I, Moriuchi H, Dateki S
J Pediatr Endocrinol Metab
. 2020 Jul;
33(7):963-966.
PMID: 32649295
Background Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand, which strongly suppresses osteoclasts. Cherubism is a rare autosomal dominant disorder characterized by symmetrical swelling of the...
7.
Worsdorfer P, I T, Asahina I, Sumita Y, Ergun S
J Neural Transm (Vienna)
. 2020 May;
127(11):1569-1577.
PMID: 32385575
3D cell culture models which closely resemble real human tissues are of high interest for disease modelling, drug screening as well as a deeper understanding of human developmental biology. Such...
8.
I T, Sumita Y, Yoshida T, Honma R, Iwatake M, Montenegro Raudales J, et al.
Stem Cell Res Ther
. 2019 Oct;
10(1):304.
PMID: 31623661
Background: There are currently no effective treatments available for patients with irreversible loss of salivary gland (SG) function caused by radiation therapy for head and neck cancer. In this study,...
9.
Kuroshima S, Nakajima K, Sasaki M, I T, Sumita Y, Asahara T, et al.
Stem Cell Res Ther
. 2019 Jul;
10(1):209.
PMID: 31311585
Background: Definitive treatment strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ) have not been developed. Cell-based therapy is an attractive treatment method for intractable diseases in the medical and dental...
10.
Egashira K, Sumita Y, Zhong W, I T, Ohba S, Nagai K, et al.
PLoS One
. 2018 Jan;
13(1):e0191099.
PMID: 29346436
Bone marrow concentrate (BMC), which is enriched in mononuclear cells (MNCs) and platelets, has recently attracted the attention of clinicians as a new optional means for bone engineering. We previously...