Takashi Hasebe
Overview
Explore the profile of Takashi Hasebe including associated specialties, affiliations and a list of published articles.
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Articles
54
Citations
622
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Recent Articles
1.
Yamada T, Furusho A, Kojima K, Sugiyama E, Mizuno H, Tsukakoshi K, et al.
Biosens Bioelectron
. 2025 Jan;
272():117108.
PMID: 39764977
We developed a novel DNA aptamer, D8#24S1, which specifically recognizes mertansine (DM1), the cytotoxic payload of the antibody-drug conjugate (ADC) trastuzumab emtansine (T-DM1), and applied it for T-DM1 analysis. D8#24S1...
2.
Nagura K, Ikeda T, Hasebe T, Satou-Kobayashi Y, Udagawa S, Shigenobu S, et al.
Dev Biol
. 2024 Sep;
517:100-116.
PMID: 39307381
During anuran metamorphosis from herbivorous tadpoles to carnivorous frogs, the gastrointestinal (GI) tract undergoes drastic remodeling, such as the formation of the stomach-intestine boundary and the development of the pyloric...
3.
Yamada T, Tsukakoshi K, Furusho A, Sugiyama E, Mizuno H, Hayashi H, et al.
Talanta
. 2024 Jun;
277:126349.
PMID: 38852342
We developed an aptamer-based fluorescence resonance energy transfer (FRET) assay capable of recognizing therapeutic monoclonal antibody bevacizumab and rapidly quantifying its concentration with just one mixing step. In this assay,...
4.
Yamashita T, Nakamoto K, Hitaoka S, Mizoguchi J, Watanabe T, Hasebe T
J Chromatogr A
. 2024 Apr;
1725:464945.
PMID: 38688053
In the field of oligonucleotides drug discovery, phosphorothioate (PS) modification has been recognized as an effective tool to overcome the nuclease digestion, and generates 2 of possible diastereomers, where n...
5.
Ena E, Asai Y, Hasebe T, Oe H, Hirose S, Takahashi Y
Yakugaku Zasshi
. 2024 Mar;
144(4):381-385.
PMID: 38556311
NMR is well known as one of the most important methods for elucidating the structure of organic compounds. Furthermore, it has recently been recognized as a powerful tool for quantitative...
6.
Uchiyama N, Hosoe J, Komatsu T, Sugimoto N, Ishizuki K, Koide T, et al.
Chem Pharm Bull (Tokyo)
. 2023 Oct;
72(1):36-40.
PMID: 37899177
The spectrum of P-NMR is fundamentally simpler than that of H-NMR; consequently identifying the target signal(s) for quantitation is simpler using quantitative P-NMR (P-qNMR) than using quantitative H-NMR (H-qNMR), which...
7.
Fujimoto K, Shibata Y, Hasebe T
J Nippon Med Sch
. 2023 Jun;
90(3):246-252.
PMID: 37380475
Intestinal homeostasis is maintained by strict regulation of stem cell function. In mammals, several signaling pathways, including the formation of stem cell niches, are involved in stem cell regulation. However,...
8.
Hasebe T, Kawamura K, Kikuyama S
Dev Growth Differ
. 2023 Jun;
38(6):605-615.
PMID: 37282231
Red blood cells (RBC) of the bullfrog (Rana catesbeiana) contain larval-type hemoglobin (Hb) during the larval period. At the beginning of metamorphosis, RBC containing adult-type Hb appear and two types...
9.
Hasebe T, Fujimoto K, Ishizuya-Oka A
Vitam Horm
. 2023 Mar;
122:1-22.
PMID: 36863790
In the amphibian intestine during metamorphosis, most of the larval epithelial cells undergo apoptosis, while a small number of the epithelial cells dedifferentiate into stem cells (SCs). The SCs actively...
10.
Uchiyama N, Kiyota K, Hosoe J, Komatsu T, Sugimoto N, Ishizuki K, et al.
Chem Pharm Bull (Tokyo)
. 2022 Oct;
70(12):892-900.
PMID: 36223954
Quantitative H-NMR (H-qNMR) is useful for determining the absolute purity of organic molecules; however, it is sometimes difficult to identify the target signal(s) for quantitation because of their overlap and...