Takao Hashiguchi
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Explore the profile of Takao Hashiguchi including associated specialties, affiliations and a list of published articles.
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74
Citations
1797
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Recent Articles
1.
Gao Z, Sasaki J, Suzuki T, Suzuki T, Miwa Y, Sando S, et al.
RSC Med Chem
. 2025 Feb;
PMID: 39925734
Fusion inhibitor peptide (FIP), a short peptide known as a measles virus (MeV) infection inhibitor, inhibits membrane fusion between the viral envelope of MeV and the host cell membrane. Therefore,...
2.
Sasaki J, Sato A, Sasaki M, Okabe I, Kodama K, Otsuguro S, et al.
Antiviral Res
. 2024 Nov;
232:106039.
PMID: 39571911
Coronaviruses such as the Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and SARS-CoV-2, causing MERS, SARS, and Coronavirus disease-19, respectively, are highly pathogenic to humans....
3.
Kuwata T, Kaku Y, Biswas S, Matsumoto K, Shimizu M, Kawanami Y, et al.
EBioMedicine
. 2024 Nov;
110:105439.
PMID: 39488016
Background: Emergence of SARS-CoV-2 variants that escape neutralising antibodies hampers the development of vaccines and therapeutic antibodies against SARS-CoV-2. IGHV3-53/3-66-derived public antibodies, which are generally specific to the prototype virus...
4.
Yajima H, Anraku Y, Kaku Y, Kimura K, Plianchaisuk A, Okumura K, et al.
Nat Commun
. 2024 Oct;
15(1):8574.
PMID: 39375326
Since 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain...
5.
Yajima H, Nomai T, Okumura K, Maenaka K, Ito J, Hashiguchi T, et al.
mBio
. 2024 Sep;
15(10):e0322023.
PMID: 39283095
Due to the incessant emergence of various SARS-CoV-2 variants with enhanced fitness in the human population, controlling the COVID-19 pandemic has been challenging. Understanding how the virus enhances its fitness...
6.
Fukuhara H, Yumoto K, Sako M, Kajikawa M, Ose T, Kawamura M, et al.
Elife
. 2024 Jul;
12.
PMID: 39046448
Canine distemper virus (CDV) belongs to morbillivirus, including measles virus (MeV) and rinderpest virus, which causes serious immunological and neurological disorders in carnivores, including dogs and rhesus monkeys, as recently...
7.
Tsujino S, Deguchi S, Nomai T, Padilla-Blanco M, Plianchaisuk A, Wang L, et al.
Microbiol Immunol
. 2024 Jul;
68(9):305-330.
PMID: 38961765
In middle to late 2023, a sublineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron XBB, EG.5.1 (a progeny of XBB.1.9.2), is spreading rapidly around the world. We performed...
8.
Paul R, Kasahara K, Sasaki J, Perez J, Matsunaga R, Hashiguchi T, et al.
Front Mol Biosci
. 2024 Mar;
10:1302737.
PMID: 38495738
Recent years have seen an uptick in the use of computational applications in antibody engineering. These tools have enhanced our ability to predict interactions with antigens and immunogenicity, facilitate humanization,...
9.
Tamura T, Irie T, Deguchi S, Yajima H, Tsuda M, Nasser H, et al.
Nat Commun
. 2024 Feb;
15(1):1176.
PMID: 38332154
Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB.1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB.1.5 evolved from XBB.1 by acquiring the S486P...
10.
Homma T, Nagata N, Hashimoto M, Iwata-Yoshikawa N, Seki N, Shiwa-Sudo N, et al.
Sci Rep
. 2024 Jan;
14(1):2599.
PMID: 38297027
No abstract available.