Takami Tomiyama
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Explore the profile of Takami Tomiyama including associated specialties, affiliations and a list of published articles.
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65
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1693
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Recent Articles
1.
Umeda T, Sakai A, Shigemori K, Nakata K, Nakajima R, Yamana K, et al.
Nutrients
. 2024 Jun;
16(11).
PMID: 38892521
The rhizomes of Schott and Solander are widely used for treating amnesia in traditional Chinese medicine. In contrast, their leaves are usually discarded without their medicinal properties being known. Here,...
2.
Chang C, Taoufiq Z, Yamada H, Takei K, Tomiyama T, Umeda T, et al.
Brain Res
. 2024 May;
1838:148987.
PMID: 38718851
Dynamin is a microtubule (MT) binding protein playing a key role in vesicle endocytosis. In a brain slice model, tau loaded in presynaptic terminals assembles MTs, thereby impairing vesicle endocytosis...
3.
Seino S, Ikehata H, Tanabe M, Umeda T, Tomiyama T, Tanaka A, et al.
J Control Release
. 2024 Jan;
367:515-521.
PMID: 38237689
This study explored the effectiveness of nasal administration in delivering magnetic nanoparticles into the brain for magnetic particle imaging of target regions. Successful delivery of iron oxide nanoparticles, which serve...
4.
Umeda T, Shigemori K, Uekado R, Matsuda K, Tomiyama T
Geroscience
. 2023 Oct;
46(2):1971-1987.
PMID: 37783918
Neurodegenerative diseases including Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies are age-related disorders and the main cause of dementia. They are characterized by the cerebral accumulation of Aβ,...
5.
Amano A, Sanjo N, Araki W, Anraku Y, Nakakido M, Matsubara E, et al.
J Nanobiotechnology
. 2023 Feb;
21(1):36.
PMID: 36721182
Background: Although a large amount of evidence has revealed that amyloid β (Aβ), especially Aβ oligomers, protofibrils, and pyroglutamated Aβs, participate primarily in the pathophysiological processes of Alzheimer's disease, most...
6.
Hatanaka Y, Umeda T, Shigemori K, Takeuchi T, Nagai Y, Tomiyama T
Biomedicines
. 2022 May;
10(5).
PMID: 35625816
The non-coding GGGGCC hexanucleotide repeat expansion (HRE) in gene is a dominant cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). This intronic mutation elicits the formation of nuclear...
7.
Shigemori K, Nomura S, Umeda T, Takeda S, Tomiyama T
Proc Natl Acad Sci U S A
. 2022 Mar;
119(12):e2117723119.
PMID: 35290109
Type 2 diabetes mellitus is known to be a risk factor for Alzheimer’s disease (AD), but the underlying mechanisms remain unclear. In AD, the cerebral accumulation of amyloid β (Aβ)...
8.
Umeda T, Uekado R, Shigemori K, Eguchi H, Tomiyama T
Biomedicines
. 2022 Feb;
10(2).
PMID: 35203506
The cell-to-cell transmission of tau aggregates is considered a mechanism underlying the intracerebral spreading of tau pathology in Alzheimer's disease (AD) and other tauopathies. Recent studies suggest that tau oligomers,...
9.
Umeda T, Sakai A, Shigemori K, Yokota A, Kumagai T, Tomiyama T
Front Neurosci
. 2021 Dec;
15:763476.
PMID: 34966254
Amyloidogenic protein oligomers are thought to play an important role in the pathogenesis of neurodegenerative dementia, including Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies. Previously we demonstrated that...
10.
Umeda T, Hatanaka Y, Sakai A, Tomiyama T
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445158
α-Synuclein oligomers are thought to play an important role in the pathogenesis of dementia with Lewy bodies (DLB). There is no effective cure for DLB at present. Previously, we demonstrated...