Takahiko Aoyama
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Explore the profile of Takahiko Aoyama including associated specialties, affiliations and a list of published articles.
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56
Citations
272
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Recent Articles
1.
Suzuki Y, Matsunaga N, Aoyama T, Ogami C, Hasegawa C, Iida S, et al.
Clin Transl Sci
. 2024 Dec;
17(12):e70097.
PMID: 39629510
The pharmacokinetics (PKs) of mycophenolic acid (MPA) exhibit considerable complexity and large variability. We developed a population pharmacokinetic (popPK) model to predict the complex PK of MPA by examining an...
2.
Hirai T, Aoyama T, Tsuji Y, Ino K, Ikejiri M, Tawara I, et al.
Eur J Drug Metab Pharmacokinet
. 2024 Sep;
49(6):763-771.
PMID: 39313741
Background And Objectives: A pharmacokinetic model has been developed to quantify the drug-drug interactions of tacrolimus with concentration-dependent inhibition of cytochrome P450 (CYP) 3A4 from voriconazole and clarithromycin based on...
3.
Hirai T, Aoyama T, Tsuji Y, Itoh T, Matsumoto Y, Iwamoto T
Br J Clin Pharmacol
. 2023 Nov;
90(3):828-836.
PMID: 37953511
Aims: Genotype-guided dosing algorithms can explain about half of the interindividual variability in prothrombin time-international normalized ratio (PT-INR) under warfarin treatment. This study aimed to refine a published kinetic-pharmacodynamic model...
4.
Hirai T, Ueda S, Ogura T, Katayama K, Dohi K, Hosohata K, et al.
J Hypertens
. 2023 Jan;
41(4):580-586.
PMID: 36655800
Objective: Mineralocorticoid receptor antagonists (MRAs), eplerenone and esaxerenone, cause hyperkalemia dose-dependently. We investigated the cytochrome P450 3A4-mediated drug-drug interaction between the MRAs and clarithromycin. Methods: This retrospective observational study included...
5.
Omori T, Aoyama T, Miyamoto A, Matsumoto Y
Biol Pharm Bull
. 2022 Nov;
45(12):1754-1763.
PMID: 36450528
Pentazocine (PTZ) is a widely used drug for postoperative pain. It should be administered at appropriate dosing intervals not only because of its morphine-like side effects but also because frequent...
6.
Aoyama T, Hirai T, Tsuji Y, Miyamoto A, Itoh T, Iwamoto T, et al.
Biol Pharm Bull
. 2022 Jan;
45(1):136-142.
PMID: 34980775
Warfarin is a representative anticoagulant with large interindividual variability. The published kinetic-pharmacodynamic (K-PD) model allows the prediction of warfarin dose requirement in Swedish patients; however, its applicability in Japanese patients...
7.
Tsuji Y, Numajiri M, Ogami C, Kurosaki F, Miyamoto A, Aoyama T, et al.
Medicine (Baltimore)
. 2021 Dec;
100(49):e28127.
PMID: 34889275
The objective of the present study was to develop a method to measure tedizolid (TZD) concentration for studying target concentration intervention, pharmacokinetics, and pharmacodynamics of TZD. We established a high-performance...
8.
Suzuki T, Fujino S, Aoyama T
J Vasc Surg Cases Innov Tech
. 2021 Aug;
7(3):520-523.
PMID: 34401616
An 84-year-old-woman was admitted because of syncope and dyspnea. She also required surgery for lumbar disc herniation. Computed tomography revealed bilateral massive pulmonary thromboembolism, deep vein thrombosis, and duplication of...
9.
Suzuki T, Fujino S, Inaba S, Yamamura R, Katoh H, Noji Y, et al.
Clin Appl Thromb Hemost
. 2020 Dec;
26:1076029620977910.
PMID: 33350315
Lung cancer is the leading cause of death from cancer in Japan. Studies in other countries have reported a venous thromboembolism (VTE) rate of 4%-20% in cancer patients. In this...
10.
Suzuki D, Aoyama T, Nakajima J, Miyamoto A, Ako Y, Kikkawa A, et al.
Ther Apher Dial
. 2020 Jan;
24(6):655-667.
PMID: 31916669
Hemodialysis (HD) is a method used to remove biogenic substances or blood components that cause disease and some drugs used by patients to treat their diseases. Therefore, dosing schedule must...