Tahnee L Saunders
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Explore the profile of Tahnee L Saunders including associated specialties, affiliations and a list of published articles.
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10
Citations
716
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Recent Articles
1.
Venkatraman R, Balka K, Wong W, Sivamani J, Magill Z, Tullett K, et al.
iScience
. 2024 Sep;
27(9):110693.
PMID: 39262777
The cGAS-STING pathway responds to cytosolic DNA to elicit host immunity to infection. The activation of stimulator of interferon genes (STING) can trigger a number of critical cellular responses including...
2.
Saunders T, Windley S, Gervinskas G, Balka K, Rowe C, Lane R, et al.
Cell Death Differ
. 2024 Feb;
31(3):335-347.
PMID: 38396150
During apoptosis mediated by the intrinsic pathway, BAX/BAK triggers mitochondrial permeabilization and the release of cytochrome-c, followed by a dramatic remodelling of the mitochondrial network that results in mitochondrial herniation...
3.
Balka K, Venkatraman R, Saunders T, Shoppee A, Pang E, Magill Z, et al.
EMBO J
. 2023 May;
42(12):e112712.
PMID: 37139896
cGAS-STING signalling is induced by detection of foreign or mislocalised host double-stranded (ds)DNA within the cytosol. STING acts as the major signalling hub, where it controls production of type I...
4.
Adiliaghdam F, Amatullah H, Digumarthi S, Saunders T, Rahman R, Wong L, et al.
Sci Immunol
. 2022 Apr;
7(70):eabn6660.
PMID: 35394816
Altered enteric microorganisms in concert with host genetics shape inflammatory bowel disease (IBD) phenotypes. However, insight is limited to bacteria and fungi. We found that eukaryotic viruses and bacteriophages (collectively,...
5.
The Australasian Cell Death Society (ACDS): celebrating 50 years of Australasian cell death research
Speir M, Chan A, Simpson D, Khan T, Saunders T, Poon I, et al.
Immunol Cell Biol
. 2021 Nov;
100(1):9-14.
PMID: 34761822
No abstract available.
6.
Chappaz S, Saunders T, Kile B
Curr Protoc
. 2021 Apr;
1(4):e79.
PMID: 33836122
The generation of radiation chimeras allows researchers to substitute the hematopoietic system of a mouse with that of one or more donors. A suspension of hematopoietic stem cells (HSCs) is...
7.
Balka K, Louis C, Saunders T, Smith A, Calleja D, DSilva D, et al.
Cell Rep
. 2020 Apr;
31(1):107492.
PMID: 32268090
Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune or autoinflammatory disease. Once activated, the cyclic guanosine monophosphate (GMP)-adenosine...
8.
Adiliaghdam F, Basavappa M, Saunders T, Harjanto D, Prior J, Cronkite D, et al.
Cell Rep
. 2020 Feb;
30(6):1690-1701.e4.
PMID: 32049003
While interferon (IFN) responses are critical for mammalian antiviral defense, induction of antiviral RNA interference (RNAi) is evident. To date, individual functions of the mammalian RNAi and micro RNA (miRNA)...
9.
McArthur K, Whitehead L, Heddleston J, Li L, Padman B, Oorschot V, et al.
Science
. 2018 Feb;
359(6378).
PMID: 29472455
Mitochondrial apoptosis is mediated by BAK and BAX, two proteins that induce mitochondrial outer membrane permeabilization, leading to cytochrome c release and activation of apoptotic caspases. In the absence of...
10.
Mehta S, Cronkite D, Basavappa M, Saunders T, Adiliaghdam F, Amatullah H, et al.
Sci Immunol
. 2017 Aug;
2(9).
PMID: 28783698
Epigenetic "readers" that recognize defined posttranslational modifications on histones have become desirable therapeutic targets for cancer and inflammation. SP140 is one such bromodomain- and plant homeodomain (PHD)-containing reader with immune-restricted...