T Tsuruo
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Explore the profile of T Tsuruo including associated specialties, affiliations and a list of published articles.
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547
Citations
8928
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Recent Articles
1.
Aggarwal S, Gupta A, Tsuruo T, Gupta S
Int J Oncol
. 2011 May;
8(6):1063-8.
PMID: 21544465
P-glycoprotein (P-gP) is a 170 kDa glycoprotein encoded by MDR1 that appears to be involved in the secretion of a large number of molecules including hormones, cyclosporin A (CSA) and...
2.
Chen Z, Naito M, Mashima T, Hiroyuki S, Tsuruo T
Methods Mol Med
. 2011 Feb;
39:681-5.
PMID: 21340830
As a genetically controlled program, apoptosis has important roles in a variety of biological processes. The realization that chemotherapy can also induce apoptosis in some cancer cells both in vitro...
3.
Takeuchi M, Kimura S, Kuroda J, Ashihara E, Kawatani M, Osada H, et al.
Cell Death Differ
. 2010 Feb;
17(7):1211-20.
PMID: 20139893
Abl tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib are ineffective against Bcr-Abl(+) leukemic stem cells. Thus, the identification of novel agents that are effective in eradicating quiescent Bcr-Abl(+)...
4.
Arnaudeau S, Arboit P, Bischof P, Shin-ya K, Tomida A, Tsuruo T, et al.
Proteomics
. 2009 Dec;
9(23):5316-27.
PMID: 20017148
Although wild-type p53 protein is overexpressed in first trimester trophoblast, it is inactive towards its target genes Metalloproteinase 2 and 9. This seems to be due to a complex mechanism...
5.
Mashima T, Seimiya H, Tsuruo T
Br J Cancer
. 2009 Apr;
100(9):1369-72.
PMID: 19352381
Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis plays an important role in tumour cell survival. These observations suggest that enzymes in the lipid synthesis pathway would...
6.
Mashima T, Seimiya H, Chen Z, Kataoka S, Tsuruo T
Cytotechnology
. 2008 Nov;
27(1-3):293-308.
PMID: 19002800
Various antitumor agents induce apoptotic cell death in tumor cells. Since the apoptosis program in tumor cells plays a critical role in the chemotherapy-induced tumor cell killing, it is suggested...
7.
Mashima T, Sato S, Sugimoto Y, Tsuruo T, Seimiya H
Oncogene
. 2008 Sep;
28(1):9-19.
PMID: 18806831
Extracellular acidosis (low pH) is a tumor microenvironmental stressor that has a critical function in the malignant progression and metastatic dissemination of tumors. To survive under stress conditions, tumor cells...
8.
Yeung B, Wong K, Lin M, Wong C, Mashima T, Tsuruo T, et al.
Br J Cancer
. 2008 Jul;
99(2):283-93.
PMID: 18594523
Chemoresistance and therapeutic selectivity are major obstacles to successful chemotherapy of ovarian cancer. Manganese superoxide disumutase (MnSOD) is an important antioxidant enzyme responsible for the elimination of superoxide radicals. We...
9.
Katayama K, Nakamura A, Sugimoto Y, Tsuruo T, Fujita N
Oncogene
. 2007 Sep;
27(12):1677-86.
PMID: 17873901
FOXO (Forkhead box O) transcription factors are involved in cell-cycle arrest or apoptosis induction by transcripting cell-cycle inhibitor p27(KIP1) or apoptosis-related genes, respectively. Akt/protein kinase B promotes cell proliferation and...
10.
Tahara H, Shin-Ya K, Seimiya H, Yamada H, Tsuruo T, Ide T
Oncogene
. 2005 Nov;
25(13):1955-66.
PMID: 16302000
Inhibition of telomerase activity by telomerase inhibitors induces a gradual loss of telomeres, and this in turn causes cancer cells to enter to a crisis stage. Here, we report the...