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T Schwecke

Explore the profile of T Schwecke including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 312
Followers 0
Related Specialties
Biochemistry
Molecular Biology
Science
Top 10 Co-Authors
I Molnar
A Konig
J F Aparicio
L E Khaw
P F Leadlay
J Staunton
S F Haydock
H van Liempt
H Palissa
G A Bohm
Published In
Eur J Biochem
Gene
Proc Natl Acad Sci U S A
Biomed Biochim Acta
FEBS Lett
Affiliations
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Recent Articles
1.
The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus
Konig A, Schwecke T, Molnar I, Bohm G, Lowden P, Staunton J, et al.
Eur J Biochem . 1997 Jul; 247(2):526-34. PMID: 9266694
An open reading frame (rapP) encoding the putative pipecolate-incorporating enzyme (PIE) has been identified in the gene cluster for the biosynthesis of rapamycin in Streptomyces hygroscopicus. Conserved amino acid sequence...
2.
Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase
Aparicio J, Molnar I, Schwecke T, Konig A, Haydock S, Khaw L, et al.
Gene . 1996 Feb; 169(1):9-16. PMID: 8635756
The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme activities, each...
3.
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase
Molnar I, Aparicio J, Haydock S, Khaw L, Schwecke T, Konig A, et al.
Gene . 1996 Feb; 169(1):1-7. PMID: 8635730
Analysis of the gene cluster from Streptomyces hygroscopicus that governs the biosynthesis of the polyketide immuno-suppressant rapamycin (Rp) has revealed that it contains three exceptionally large open reading frames (ORFs)...
4.
Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases
Haydock S, Aparicio J, Molnar I, Schwecke T, Khaw L, Konig A, et al.
FEBS Lett . 1995 Oct; 374(2):246-8. PMID: 7589545
The amino acid sequences of a large number of polyketide synthase domains that catalyse the transacylation of either methylmalonyl-CoA or malonyl-CoA onto acyl carrier protein (ACP) have been compared. Regions...
5.
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin
Schwecke T, Aparicio J, Molnar I, Konig A, Khaw L, Haydock S, et al.
Proc Natl Acad Sci U S A . 1995 Aug; 92(17):7839-43. PMID: 7644502
The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and specific alteration of the biosynthetic genes...
6.
Enzymatic characterisation of the multifunctional enzyme delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus
Schwecke T, Aharonowitz Y, Palissa H, Von Dohren H, Kleinkauf H, van Liempt H
Eur J Biochem . 1992 Apr; 205(2):687-94. PMID: 1572368
delta-(L-alpha-Aminoadipyl)-L-cysteinyl-D-valine (ACV) synthetase, the multienzyme catalyzing the formation of ACV from the constituent amino acids and ATP in the presence of Mg2+ and dithioerythritol, was purified about 2700-fold from Streptomyces...
7.
Principles of the molecular construction of multienzyme templates for peptide biosynthesis in integrated reaction sequences
van Liempt H, Pfeifer E, Schwecke T, Palissa H, von Doehren H
Biomed Biochim Acta . 1991 Jan; 50(10-11):S256-9. PMID: 1820055
The amino acid sequences of the genes coding for four multienzyme peptide synthetases, operating by the thiotemplate mechanism are compared, to show underlying principles in the biosynthetic mechanism. Alignment with...