T Sarna
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Explore the profile of T Sarna including associated specialties, affiliations and a list of published articles.
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62
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1055
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Recent Articles
1.
Gkogkolou P, Sarna M, Sarna T, Paus R, Luger T, Bohm M
Br J Dermatol
. 2018 Sep;
180(4):836-848.
PMID: 30171686
Background: Chronic skin ulcers are a major complication and a therapeutic challenge in patients with diabetes mellitus. Glucose-induced accumulation of reactive oxygen species (ROS) is considered to be an important...
2.
Koscielniak A, Serafin M, Duda M, Oles T, Zadlo A, Broniec A, et al.
Cell Biochem Biophys
. 2017 Nov;
75(3-4):443-454.
PMID: 29098642
The mammalian retina contains a high level of polyunsaturated fatty acids, including docosahexaenoic acid (22:6) (DHA), which are highly susceptible to oxidation. It has been shown that one of the...
3.
Broniec A, Zadlo A, Pawlak A, Fuchs B, Klosinski R, Thompson D, et al.
Free Radic Biol Med
. 2017 Feb;
106:368-378.
PMID: 28232206
Plasmalogens (Plg) - naturally occurring glycerophospholipids with the vinyl-ether group in the sn-1 position are generally viewed as physiological antioxidants. Although there are numerous examples of antioxidant action of plasmalogen...
4.
Nowak-Sliwinska P, Weiss A, van Beijnum J, Wong T, Kilarski W, Szewczyk G, et al.
Cell Death Dis
. 2015 Feb;
6:e1641.
PMID: 25675301
The angiogenesis inhibitor sunitinib is a tyrosine kinase inhibitor that acts mainly on the VEGF and PDGF pathways. We have previously shown that sunitinib is sequestered in the lysosomes of...
5.
Adar Y, Stark M, Bram E, Nowak-Sliwinska P, van den Bergh H, Szewczyk G, et al.
Cell Death Dis
. 2012 Apr;
3:e293.
PMID: 22476101
Multidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is...
6.
Wolnicka-Glubisz A, Fraczek J, Skrzeczynska-Moncznik J, Friedlein G, Mikolajczyk T, Sarna T, et al.
J Physiol Pharmacol
. 2010 Mar;
61(1):107-14.
PMID: 20228422
Photopheresis (ECP) is an immunomodulatory therapy that involves extracorporeal exposure of isolated peripheral blood leukocytes to UVA irradiation in the presence of 8-methoxypsoralen (8-MOP) followed by their reinfusion to the...
7.
Cantrell A, McGarvey D, Roberts J, Sarna T, Truscott T
J Photochem Photobiol B
. 2001 Dec;
64(2-3):162-5.
PMID: 11744402
Lipofuscin is thought to be involved in age-related macular degeneration as is one of its proposed components, an amphiphillic pyridinium-based bis-retinoid with a quaternary nitrogen atom, known as A2-E. We...
8.
Lamb L, Zareba M, Plakoudas S, Sarna T, Simon J
Arch Biochem Biophys
. 2001 Sep;
393(2):316-20.
PMID: 11556819
Lipofuscin accumulation in the retinal pigment epithelium is associated with the onset of age-related macular degeneration. Lipofuscin is phototoxic and affects cellular function through the photochemical generation of reactive oxygen...
9.
Lamb L, Simon J, Krogmeier J, DUNN R, Pawlak A, Rozanowska M, et al.
Photochem Photobiol
. 2001 Sep;
74(2):364-8.
PMID: 11547578
The emission spectra of single lipofuscin granules are examined using spectrally resolved confocal microscopy and near-field scanning optical microscopy (NSOM). The emission spectrum varies among the granules examined revealing that...
10.
Davies S, Elliott M, Floor E, Truscott T, Zareba M, Sarna T, et al.
Free Radic Biol Med
. 2001 Jul;
31(2):256-65.
PMID: 11440838
Lipofuscin accumulates with age in a variety of highly metabolically active cells, including the retinal pigment epithelium (RPE) of the eye, where its photoreactivity has the potential for cellular damage....