T P Malan Jr
Overview
Explore the profile of T P Malan Jr including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
1005
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Recent Articles
1.
Lai J, Ossipov M, Vanderah T, Malan Jr T, Porreca F
Mol Interv
. 2004 Mar;
1(3):160-7.
PMID: 14993349
One of the curious but common consequences of opioid administration in the clinical setting is the induction, at sites uninvolved in the original presentation of discomfort, of pain itself. The...
2.
Gardell L, Ibrahim M, Wang R, Wang Z, Ossipov M, Malan Jr T, et al.
Neuroscience
. 2003 Dec;
123(1):43-52.
PMID: 14667440
Several experimental models of peripheral neuropathy show that a significant upregulation of spinal dynorphin A and its precursor peptide, prodynorphin, is a common consequence of nerve injury. A genetically modified...
3.
Ibrahim M, Mata H, Chawla M, Lai J, Porreca F, Malan Jr T
J Pain
. 2003 Nov;
2(4):241-9.
PMID: 14622822
Inhibition of spinal Fos expression increases formalin-induced nociception and decreases spinal prodynorphin messenger ribonucleic acid (mRNA), suggesting that Fos modulates nociception by inducing dynorphin synthesis. This study tests the hypothesis...
4.
Gentz B, Malan Jr T
Drugs
. 2002 Jan;
61(15):2155-62.
PMID: 11772127
The inhaled anaesthetic sevoflurane is metabolised into two products that have the potential to produce renal injury. Fluoride ions are produced by oxidative defluorination of sevoflurane by the cytochrome P450...
5.
Malan Jr T, Nolan P, Lichtenthal P, POLSON J, Tebich S, Bose R, et al.
Anesthesiology
. 2001 Jul;
95(1):264-6.
PMID: 11465569
No abstract available.
6.
Porreca F, Burgess S, Gardell L, Vanderah T, Malan Jr T, Ossipov M, et al.
J Neurosci
. 2001 Jul;
21(14):5281-8.
PMID: 11438603
Neurons in the rostroventromedial medulla (RVM) project to spinal loci where the neurons inhibit or facilitate pain transmission. Abnormal activity of facilitatory processes may thus represent a mechanism of chronic...
7.
Simoneau I, Hamza M, Mata H, Siegel E, Vanderah T, Porreca F, et al.
Anesthesiology
. 2001 Jun;
94(5):882-7.
PMID: 11388542
Background: Cannabinoid receptor agonists reverse nausea and vomiting produced by chemotherapy and radiation therapy in animals and humans but have not been tested against opioid-induced emesis. This study tests the...
8.
Vanderah T, Ossipov M, Lai J, Malan Jr T, Porreca F
Pain
. 2001 Apr;
92(1-2):5-9.
PMID: 11323121
No abstract available.
9.
Wang Z, Gardell L, Ossipov M, Vanderah T, Brennan M, Hochgeschwender U, et al.
J Neurosci
. 2001 Feb;
21(5):1779-86.
PMID: 11222667
Whereas tissue injury increases spinal dynorphin expression, the functional relevance of this upregulation to persistent pain is unknown. Here, mice lacking the prodynorphin gene were studied for sensitivity to non-noxious...
10.
Vanderah T, Suenaga N, Ossipov M, Malan Jr T, Lai J, Porreca F
J Neurosci
. 2001 Jan;
21(1):279-86.
PMID: 11150345
Many clinical case reports have suggested that sustained opioid exposure can elicit unexpected, paradoxical pain. Here, we explore the possibility that (1) opioid-induced pain results from tonic activation of descending...