T M Saxton
Overview
Explore the profile of T M Saxton including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
12
Citations
754
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Saxton T, Cheng A, Ong S, Lu Y, Sakai R, CROSS J, et al.
Curr Biol
. 2001 May;
11(9):662-70.
PMID: 11369229
Background: The mammalian Grb2 adaptor protein binds pTyr-X-Asn motifs through its SH2 domain, and engages downstream targets such as Sos1 and Gab1 through its SH3 domains. Grb2 thereby couples receptor...
2.
Sakai R, Henderson J, OBryan J, Elia A, Saxton T, Pawson T
Neuron
. 2001 Feb;
28(3):819-33.
PMID: 11163269
Shc proteins possess SH2 and PTB domains and serve a scaffolding function in signaling by a variety of receptor tyrosine kinases. There are three known mammalian Shc genes, of which...
3.
Saxton T, Ciruna B, Holmyard D, Kulkarni S, Harpal K, Rossant J, et al.
Nat Genet
. 2000 Mar;
24(4):420-3.
PMID: 10742110
The tyrosine phosphatase Shp2 is recruited into tyrosine-kinase signalling pathways through binding of its two amino-terminal SH2 domains to specific phosphotyrosine motifs, concurrent with its re-localization and stimulation of phosphatase...
4.
5.
Saxton T, Pawson T
Proc Natl Acad Sci U S A
. 1999 Mar;
96(7):3790-5.
PMID: 10097116
The SH2 domain-containing tyrosine phosphatase Shp2 plays a pivotal role during the gastrulation of vertebrate embryos. However, because of the complex phenotype observed in mouse mutant embryos, the precise role...
6.
Oh E, Gu H, Saxton T, Timms J, Hausdorff S, Frevert E, et al.
Mol Cell Biol
. 1999 Mar;
19(4):3205-15.
PMID: 10082587
The nontransmembrane protein tyrosine phosphatase SHP-2 plays a critical role in growth factor and cytokine signaling pathways. Previous studies revealed that a fraction of SHP-2 moves to focal contacts upon...
7.
Cheng A, Saxton T, Sakai R, Kulkarni S, Mbamalu G, Vogel W, et al.
Cell
. 1998 Dec;
95(6):793-803.
PMID: 9865697
Proteins with SH2 and SH3 domains link tyrosine kinases to intracellular pathways. To investigate the biological functions of a mammalian SH2/SH3 adaptor, we have introduced a null mutation into the...
8.
Saxton T, Henkemeyer M, Gasca S, Shen R, Rossi D, Shalaby F, et al.
EMBO J
. 1997 May;
16(9):2352-64.
PMID: 9171349
Shp-1, Shp-2 and corkscrew comprise a small family of cytoplasmic tyrosine phosphatases that possess two tandem SH2 domains. To investigate the biological functions of Shp-2, a targeted mutation has been...
9.
Henkemeyer M, Orioli D, Henderson J, Saxton T, Roder J, Pawson T, et al.
Cell
. 1996 Jul;
86(1):35-46.
PMID: 8689685
Eph family receptor tyrosine kinases have been proposed to control axon guidance and fasciculation. To address the biological functions of the Eph family member Nuk, two mutations in the mouse...
10.
Gold M, Chiu R, Ingham R, Saxton T, Van Oostveen I, Watts J, et al.
J Immunol
. 1994 Sep;
153(6):2369-80.
PMID: 8077654
We show that cross-linking the B cell AgR with anti-Ig Abs activates p56lck (Lck) in both the immature B cell line WEHI-231 and mature resting B cells from mouse spleen....